With the support of the award Lie will extend his group of young scientists at the GSF Institute of Development Genetics, which was established in spring 2005. Since 1999 he has been working on the mechanisms of hippocampal neurogenesis, i.e., the formation of new nerve cells in the adult hippocampus. This brain region plays a central role in learning and memory processes.
“In the future my EURYI group will work on the identification of the signals regulating the quiescent state of stem cells,” Dieter Chichung Lie emphasizes. “To this end, we will apply state of the art techniques in genetics, molecular biology and cell biology.” The researchers envision that these studies will contribute to the development of new strategies for the treatment of learning and memory disorders and that these studies will provide new insights into the development of brain tumours.
Background: in the adult brain the majority of nerve cells are generated from neural stem cells during embryonal development or shortly after birth. The hippocampus is one of two specialised brain regions in which neurogenesis continues throughout adulthood. Recent results indicate that neurogenesis contributes to the function of the hippocampus: in aging animals the rate of hippocampal neurogenesis continuously decreases and is paralleled by learning and memory deficits.
The formation of new nerve cells from stem cells in the adult hippocampus is subject to tight control: insufficient formation of new nerve cells might lead to malfunction of the hippocampus. In contrast, excessive formation of new cells may result in the exhaustion of the stem cell pool, which would lead to early impairment of hippocampal function. Apart from that, uncontrolled formation of new cells would pose the risk of tumour formation.
The adult brain has developed a protective strategy: the majority of adult neural stem cells are in a quiescent state, i.e., non-proliferative. They have to be activated from the quiescent state, in order to divide and form new nerve cells in the hippocampus.
Since 2004 the European Science Foundation has been awarding the EURYI Award, which provides outstanding young scientists from all disciplines with the financial means and human resources to establish their research groups in Europe. The objective of the EURYI Awards is to recruit and keep talented young scientists for research in Europe. To this end the scientists are provided with funding that allows them to conduct research on an internationally competitive level. Apart from scientific excellence, the innovation content of the research projects is a major selection criteria.
Michael van den Heuvel | alfa
Designer cells: artificial enzyme can activate a gene switch
22.05.2018 | Universität Basel
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
22.05.2018 | Life Sciences
22.05.2018 | Earth Sciences
22.05.2018 | Trade Fair News