Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein important in blood clotting may also play a role in fertility

23.10.2006
A protein known to play a role in blood clotting and other cell functions is also critical for proper sperm formation in mice, according to researchers from the University of North Carolina at Chapel Hill School of Medicine.

Male mice missing both copies of the gene that produces the protein, called CIB1, have testes about half the normal size, have smaller numbers of the cells that give rise to sperm and produce no mature sperm at all, the researchers found. Female mice missing CIB1 were fertile, as were males missing only one copy of the CIB1 gene. Mice, like humans, have two copies of every gene, one from each parent.

The serendipitous discovery occurred when lead study author Dr. Weiping Yuan, intending to study CIB1's role in blood clotting, bred mice missing the CIB1 gene. All male mice bred without both copies of the gene were infertile, said Yuan, UNC research assistant professor of pharmacology.

CIB1 joins a growing list of fertility genes discovered during the course of mice studies of diseases such as cancer, diabetes and heart disease. In 2000, UNC researchers found several genes essential for male mouse fertility while studying how cells transport chloride, sodium and potassium, Yuan notes.

... more about:
»CIB1 »Yuan »blood »clotting »fertility »sperm

The results appear online in advance of print publication in the journal Molecular and Cell Biology. The study was funded by the National Institutes of Child Health and Human Development, part of the National Institutes of Health.

Earlier work by Yuan and his colleagues showed CIB1 helps control blood clotting in humans by keeping blood platelets from sticking together, acting as a natural anti-coagulant to prevent uncontrolled clotting of blood platelets that might lead to heart attacks and strokes.

From initial observations, the CIB1 defect in mice appears to disrupt sperm formation in its final stage, said Dr. Deborah O'Brien, study co-author and an associate professor of cell and developmental biology. "To make a sperm, you have to go from a fairly typical cell to one that has a very distinctive shape and half the number of chromosomes," O'Brien said. "The male mice missing CIB1 appear to have a problem very late in this process, when the cell differentiates into a sperm cell."

Further study would be needed to determine if the finding has implications for human infertility, O'Brien said. "If the protein has the same expression pattern and role in humans, then I would expect that a defect in this protein should have the same effect in humans. Some infertility could be due to a mutation in CIB1, but that's far down the road."

The discovery suggests that CIB1 is a major regulatory protein, active in cell function throughout the body, said Dr. Leslie Parise, senior author, professor of biochemistry and biophysics and pharmacology and chair of the department of biochemistry and biophysics. "This protein is known to regulate cell migration in other cells. Whether that ability is linked to this problem with spermatogenesis, we don't know," said Parise, who discovered CIB1 in 1997. "It will take further research to determine exactly how CIB1 regulates sperm formation."

L. H. Lang | EurekAlert!
Further information:
http://www.med.unc.edu

Further reports about: CIB1 Yuan blood clotting fertility sperm

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>