In a study published today in the open access journal Respiratory Research (http://respiratory-research.com/), researchers have created antibodies against the avian flu virus H5N1 that work in mice both as a preventive drug, or prophylaxis, when administered before infection, and as a treatment for bird flu. These antibodies are part human, part mouse antibodies and would be less likely to be rejected by the human immune system than pure mouse antibodies.
Brendon Hanson and colleagues from the DSO National Laboratories in Singapore, in collaboration with Richard Webby and colleagues from St Jude Children’s Research Hospital in Memphis, USA created two different antibodies able to recognise slightly different types of H5N1 viruses. The antibodies were ‘humanised’ mouse antibodies – they comprised both human and mouse antibody fragments. The antibodies were injected into mice 24 hours before the mice received a potentially lethal dose of H5N1. Other groups of mice were injected with the antibodies one day or three days after receiving the lethal dose of H5N1.
Hanson et al.’s results show that prophylactic use of a low dose (1mg/kg) of the first antibody completely protects the mice from disease and death caused by H5N1. Higher doses are necessary to completely protect the mice from disease and death when administered one (5mg/kg) or three (10mg/kg) days after infection. The second antibody is less effective and only protects the mice from disease when given at a high dose (5mg/kg) 24 hours before infection.
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28.03.2017 | Aarhus University
Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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