In a study published today in the open access journal Respiratory Research (http://respiratory-research.com/), researchers have created antibodies against the avian flu virus H5N1 that work in mice both as a preventive drug, or prophylaxis, when administered before infection, and as a treatment for bird flu. These antibodies are part human, part mouse antibodies and would be less likely to be rejected by the human immune system than pure mouse antibodies.
Brendon Hanson and colleagues from the DSO National Laboratories in Singapore, in collaboration with Richard Webby and colleagues from St Jude Children’s Research Hospital in Memphis, USA created two different antibodies able to recognise slightly different types of H5N1 viruses. The antibodies were ‘humanised’ mouse antibodies – they comprised both human and mouse antibody fragments. The antibodies were injected into mice 24 hours before the mice received a potentially lethal dose of H5N1. Other groups of mice were injected with the antibodies one day or three days after receiving the lethal dose of H5N1.
Hanson et al.’s results show that prophylactic use of a low dose (1mg/kg) of the first antibody completely protects the mice from disease and death caused by H5N1. Higher doses are necessary to completely protect the mice from disease and death when administered one (5mg/kg) or three (10mg/kg) days after infection. The second antibody is less effective and only protects the mice from disease when given at a high dose (5mg/kg) 24 hours before infection.
Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel
Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
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25.05.2018 | Life Sciences