In a study published today in the open access journal Respiratory Research (http://respiratory-research.com/), researchers have created antibodies against the avian flu virus H5N1 that work in mice both as a preventive drug, or prophylaxis, when administered before infection, and as a treatment for bird flu. These antibodies are part human, part mouse antibodies and would be less likely to be rejected by the human immune system than pure mouse antibodies.
Brendon Hanson and colleagues from the DSO National Laboratories in Singapore, in collaboration with Richard Webby and colleagues from St Jude Children’s Research Hospital in Memphis, USA created two different antibodies able to recognise slightly different types of H5N1 viruses. The antibodies were ‘humanised’ mouse antibodies – they comprised both human and mouse antibody fragments. The antibodies were injected into mice 24 hours before the mice received a potentially lethal dose of H5N1. Other groups of mice were injected with the antibodies one day or three days after receiving the lethal dose of H5N1.
Hanson et al.’s results show that prophylactic use of a low dose (1mg/kg) of the first antibody completely protects the mice from disease and death caused by H5N1. Higher doses are necessary to completely protect the mice from disease and death when administered one (5mg/kg) or three (10mg/kg) days after infection. The second antibody is less effective and only protects the mice from disease when given at a high dose (5mg/kg) 24 hours before infection.
Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
16.01.2017 | Power and Electrical Engineering
16.01.2017 | Information Technology
16.01.2017 | Power and Electrical Engineering