Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pioneering research to discover how a gene normally responsible for growth in unborn babies, ...

04.10.2006
...is linked to certain cancers, is being carried out by a leading scientist in Cambridge.

Dr Adele Murrell has been awarded a grant from AICR (the Association for International Cancer Research) to study the strange behaviour of a gene called IGF2.

She explains: “We know that if this gene is over-active in the embryo, it results in overgrowth and can cause a rare but distressing syndrome that can lead to certain childhood cancers. Over-activity of the gene has also been reported in many adult cancers, including breast and bowel cancer.

“ Normally, we inherit two copies of our genes, one from our mother and the other from our father. Some of our genes, including IGF2, have the ability to remember their origin. We call this ‘imprinting.’ In the developing embryo, it is only the paternal IGF2 gene – the one from the father – that is active. However, it is the maternal IGF2 gene that can sometimes become active in adult cells and lead to the formation of a cancer.”

... more about:
»IGF2 »Murrell »cause

Scientists have discovered that imprinting is caused by subtle chemical changes to the structure of the DNA or the proteins associated with it. Now, with AICR support, Dr Murrell will investigate further proteins involved with the imprinting of the IFG2 gene to find out how this system is involved when this gene causes cancer.

Dr Mark Matfield, AICR’s scientific adviser believes the work may have significant implications for treating the disease in the future. “Imprinting is a way of turning specific genes on or off. Since problems with gene structure or activity are the fundamental cause of cancer, turning those ‘rogue’ genes off could be the basis of a new method of treatment.”

Derek Napier, AICR's Chief Executive says the grant awarded to Dr Murrell has been given in line with the charity's policy of funding the most exciting and novel approaches to research worldwide. " We believe it important to fund work that pushes the boundaries and Dr Murrell and her team are charged with tackling one of the greatest scientific challenges of all.”

Susan Osborne | alfa
Further information:
http://www.aicr.org.uk

Further reports about: IGF2 Murrell cause

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>