Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


A spicy solution for colon cancer?

Looking for a cancer cure? Try the spice rack.

In the last few years, that tactic has proved productive for researchers investigating turmeric, a curry spice used for centuries in Indian traditional medicine.

They've found that turmeric's active ingredient, curcumin, works in the lab to fight skin, breast and other tumor cells. In fact, human clinical trials employing curcumin have already been launched.

Now, working with cell cultures in a laboratory, scientists at the University of Texas Medical Branch at Galveston (UTMB) have discovered that curcumin blocks the activity of a gastrointestinal hormone implicated in the development of colorectal cancer, the country's second leading cancer killer with nearly 60,000 deaths annually. In a paper published in the current issue of Clinical Cancer Research, the UTMB researchers link the gastrointestinal hormone neurotensin, which is generated in response to fat consumption, to the production of IL-8, a potent inflammatory protein that accelerates the growth and spread of a variety of human cancer cells, including colorectal and pancreatic tumor cells.

"We found that in colon cancer cells, neurotensin increases not just the rate of growth but also other critical things, including cell migration and metastasis," said UTMB surgery professor B. Mark Evers, senior author of the article and director of UTMB's Sealy Center for Cancer Cell Biology. "The fact that all that can be turned off by this natural product, curcumin, was really remarkable."

Evers' group, including lead author and UTMB research associate Xiaofu Wang, probed curcumin's effect on the process by which neurotensin stimulates colon cancer cells to generate IL-8 in detail.

Neurotensin's influence, they found, depends on biochemical signaling pathways inside the cell. Their experiments showed that curcumin damped down those signals, reducing the production of IL-8. Experiments also showed that neurotensin increased the migration of colorectal cancer cells, and that curcumin could suppress this migration -- possibly reducing the ability of colorectal cancer to spread to other locations in the body.

"Our findings suggest that curcumin may be useful for colon cancer treatment, as well as potential colon cancer suppression, in cells that respond to this gastrointestinal hormone, neurotensin," Evers said. "About a third of all colorectal cancer cells have the receptor for neurotensin. Thus, the concept would be sort of like what we do for breast and prostate cancer, where the main therapy involves blocking hormones. We hope to do similar things with gastrointestinal cancers that respond to this hormone."

Jim Kelly | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>