In the last few years, that tactic has proved productive for researchers investigating turmeric, a curry spice used for centuries in Indian traditional medicine.
They've found that turmeric's active ingredient, curcumin, works in the lab to fight skin, breast and other tumor cells. In fact, human clinical trials employing curcumin have already been launched.
Now, working with cell cultures in a laboratory, scientists at the University of Texas Medical Branch at Galveston (UTMB) have discovered that curcumin blocks the activity of a gastrointestinal hormone implicated in the development of colorectal cancer, the country's second leading cancer killer with nearly 60,000 deaths annually. In a paper published in the current issue of Clinical Cancer Research, the UTMB researchers link the gastrointestinal hormone neurotensin, which is generated in response to fat consumption, to the production of IL-8, a potent inflammatory protein that accelerates the growth and spread of a variety of human cancer cells, including colorectal and pancreatic tumor cells.
"We found that in colon cancer cells, neurotensin increases not just the rate of growth but also other critical things, including cell migration and metastasis," said UTMB surgery professor B. Mark Evers, senior author of the article and director of UTMB's Sealy Center for Cancer Cell Biology. "The fact that all that can be turned off by this natural product, curcumin, was really remarkable."
Evers' group, including lead author and UTMB research associate Xiaofu Wang, probed curcumin's effect on the process by which neurotensin stimulates colon cancer cells to generate IL-8 in detail.
Neurotensin's influence, they found, depends on biochemical signaling pathways inside the cell. Their experiments showed that curcumin damped down those signals, reducing the production of IL-8. Experiments also showed that neurotensin increased the migration of colorectal cancer cells, and that curcumin could suppress this migration -- possibly reducing the ability of colorectal cancer to spread to other locations in the body.
"Our findings suggest that curcumin may be useful for colon cancer treatment, as well as potential colon cancer suppression, in cells that respond to this gastrointestinal hormone, neurotensin," Evers said. "About a third of all colorectal cancer cells have the receptor for neurotensin. Thus, the concept would be sort of like what we do for breast and prostate cancer, where the main therapy involves blocking hormones. We hope to do similar things with gastrointestinal cancers that respond to this hormone."
Jim Kelly | EurekAlert!
Study suggests oysters offer hot spot for reducing nutrient pollution
17.10.2017 | Virginia Institute of Marine Science
World first for reading digitally encoded synthetic molecules
17.10.2017 | CNRS
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
17.10.2017 | Life Sciences
17.10.2017 | Physics and Astronomy
17.10.2017 | Life Sciences