Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Fatty acids and caveolin-1 are essential in liver regeneration

Liver regulates lipid, carbohydrate and protein metabolism. It also segregates a number of proteins and enzymes, and eliminates toxic substances from the organism. Liver regeneration is a mostly unknown process at a molecular level, although it is essential for the good functioning of the liver, and indispensable in order to carry out some therapeutic strategies, such as living-donor transplant.
The journal Science [

=16973879&query_hl=1&itool=pubmed_docsum] publishes in its next issue a research article where researchers from IDIBAPS, in collaboration with Universitat de Barcelona (UB) and Queensland University (Australia) discover the importance of caveolin-1 in liver regeneration. Without this protein, regeneration does not occur. This research work has been directed by Dr. Albert Pol, one of the first researchers with a Ramón y Cajal contract; and Dr. Carles Enrich, from the Department of Cell Biology and Pathological Anatomy from the Faculty of Medicine of the UB. The first signatories of this article are Manuel A. Fernández and Cecilia Albor.

Stem cells do not participate in liver regeneration, but hepatocytes, cells of the liver tissue, are able to regain their division capacity when needed. In a normal liver, hepatocytes do not divide, but during regeneration, all liver cells duplicate at least once. For this system to function, a fine regulation system is needed, permitting the hepatocyte to accumulate energetic reserves in the form of lipid accumulations, and starting the genetic machinery for division. IDIBAPS researchers studied the role of caveolin-1 in this process, comparing the regenerative capacity of normal mice and modified mice, which do not express the caveolin-1 gene. Both types of mice were extirpated 70% of their liver mass, and differences in regeneration process were analysed through microscopic and molecular techniques.

... more about:
»Caveolin-1 »Regeneration »hepatocyte »liver

During the first stages of regeneration, liver cells accumulate a large amount of lipids in structures called lipidic bodies, whose importance was until today unknown. This study published in Science demonstrates that the energy needed in liver regeneration comes from lipids accumulated in liver cells during the first hours of the process. Genetically modified mice, not expressing caveolin-1, were incapable of forming the lipidic bodies necessary in order to provide energy for the regeneration. After 48 hours of the extraction of a part of the liver, the mortality of modified mice increased, and, after 72 hours, only 22% survived, whereas normal mice survived in 89% of cases. Similar results were obtained by avoiding caveolin-1 expression with the interference RNA technique, and the administration of glucose in mice without caveolin allowed them to have an alternative energy source and were able to regenerate liver with more normality.

Summarising, this work makes two important contributions: On the one hand, it reveals the main vital function of lipid bodies and caveolin. This is a protein linked to the storage of lipids and cell cycle, but a situation where its presence is indispensable for the survival of experimental animals has been described in this study for the first time. On the other hand, the article published in Science demonstrates that lipids can be the fuel for cell division, whereas until today, it was assumed that glucose was its first energy source. This discovery could explain why steatosis, a disease where an excessive accumulation of lipids in the liver, is considered a risk factor for the apparition of hepatocellular tumours. The excessive accumulation of lipids in the hepatocyte, as a consequence of excessive consumption of nutrients, obesity, type-2 diabetes or due to a bad liver functioning, affects in several degrees up to two thirds of the population in developed countries. Our researchers claim that an excess of lipid could represent for these cells an energy source sufficient to proliferate inadequately and, thus, to develop hepatic tumours.

Àlex Argemí Saburit | alfa
Further information:

Further reports about: Caveolin-1 Regeneration hepatocyte liver

More articles from Life Sciences:

nachricht Don't Give the Slightest Chance to Toxic Elements in Medicinal Products
23.03.2018 | Physikalisch-Technische Bundesanstalt (PTB)

nachricht North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>