Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fatty acids and caveolin-1 are essential in liver regeneration

19.09.2006
Liver regulates lipid, carbohydrate and protein metabolism. It also segregates a number of proteins and enzymes, and eliminates toxic substances from the organism. Liver regeneration is a mostly unknown process at a molecular level, although it is essential for the good functioning of the liver, and indispensable in order to carry out some therapeutic strategies, such as living-donor transplant.
The journal Science [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids

=16973879&query_hl=1&itool=pubmed_docsum] publishes in its next issue a research article where researchers from IDIBAPS, in collaboration with Universitat de Barcelona (UB) and Queensland University (Australia) discover the importance of caveolin-1 in liver regeneration. Without this protein, regeneration does not occur. This research work has been directed by Dr. Albert Pol, one of the first researchers with a Ramón y Cajal contract; and Dr. Carles Enrich, from the Department of Cell Biology and Pathological Anatomy from the Faculty of Medicine of the UB. The first signatories of this article are Manuel A. Fernández and Cecilia Albor.

Stem cells do not participate in liver regeneration, but hepatocytes, cells of the liver tissue, are able to regain their division capacity when needed. In a normal liver, hepatocytes do not divide, but during regeneration, all liver cells duplicate at least once. For this system to function, a fine regulation system is needed, permitting the hepatocyte to accumulate energetic reserves in the form of lipid accumulations, and starting the genetic machinery for division. IDIBAPS researchers studied the role of caveolin-1 in this process, comparing the regenerative capacity of normal mice and modified mice, which do not express the caveolin-1 gene. Both types of mice were extirpated 70% of their liver mass, and differences in regeneration process were analysed through microscopic and molecular techniques.

... more about:
»Caveolin-1 »Regeneration »hepatocyte »liver

During the first stages of regeneration, liver cells accumulate a large amount of lipids in structures called lipidic bodies, whose importance was until today unknown. This study published in Science demonstrates that the energy needed in liver regeneration comes from lipids accumulated in liver cells during the first hours of the process. Genetically modified mice, not expressing caveolin-1, were incapable of forming the lipidic bodies necessary in order to provide energy for the regeneration. After 48 hours of the extraction of a part of the liver, the mortality of modified mice increased, and, after 72 hours, only 22% survived, whereas normal mice survived in 89% of cases. Similar results were obtained by avoiding caveolin-1 expression with the interference RNA technique, and the administration of glucose in mice without caveolin allowed them to have an alternative energy source and were able to regenerate liver with more normality.

Summarising, this work makes two important contributions: On the one hand, it reveals the main vital function of lipid bodies and caveolin. This is a protein linked to the storage of lipids and cell cycle, but a situation where its presence is indispensable for the survival of experimental animals has been described in this study for the first time. On the other hand, the article published in Science demonstrates that lipids can be the fuel for cell division, whereas until today, it was assumed that glucose was its first energy source. This discovery could explain why steatosis, a disease where an excessive accumulation of lipids in the liver, is considered a risk factor for the apparition of hepatocellular tumours. The excessive accumulation of lipids in the hepatocyte, as a consequence of excessive consumption of nutrients, obesity, type-2 diabetes or due to a bad liver functioning, affects in several degrees up to two thirds of the population in developed countries. Our researchers claim that an excess of lipid could represent for these cells an energy source sufficient to proliferate inadequately and, thus, to develop hepatic tumours.

Àlex Argemí Saburit | alfa
Further information:
http://www.idibaps.ub.edu

Further reports about: Caveolin-1 Regeneration hepatocyte liver

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>