They have found out that the lack or inhibition of the protein it represents decreases the speed at which neoplasias occur, as it prevents the inflammation that contributes to the proliferation of cancer cells. Part of the conclusions of this research work are published in the June edition of the journal 'Cancer Research'.
Experts have used a model of experimental carcinogenesis, that is, have caused cancer in normal experimental mice and also in mice knocked out in that specific gene. After many experiments, they have found out that apart from collaborating to the DNA repair, the parp-1 gene has an influence on the growth of the carcinoma. Moreover, the gene’s lack of expression obstructs the angiogenesis process, which causes the creation of new blood vessels that allow sick cells to survive by receiving nourishment from the host organism.
The novelty of this finding is the possibility of designing new strategies that inhibit protein parp-1 activity in order to stop the progression of cancer. The next step consists of checking in experimentation models the efficacy of inhibitors in the treatment of cancer processes. So far, experts have used molecular medicines to carry out this delay process.
Researchers are trying to find more efficient therapeutical strategies that reinforce the action of antitumoral agents and decrease the administered radiation or chemotherapy doses. This way, the side effects will also decrease.
USA-based scientists have recently proven that this enzyme which repairs sick cells and keeps cell energy could be useful for the treatment of Huntington’s disease and other pathologies characterised by a low level of energy in cells. This is what an article published in the Chemistry & Biologyen’s August edition reveals, written by researchers of the Institute for Neurodegenerative Disease of Massachusetts General Hospital. These experts describe a new inhibitor of polymerase Parp1 which protects the cells affected by the Huntington’s disease in a lab.
Ismael Gaona | alfa
Copper hydroxide nanoparticles provide protection against toxic oxygen radicals in cigarette smoke
29.05.2017 | Johannes Gutenberg-Universität Mainz
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
29.05.2017 | Physics and Astronomy
29.05.2017 | Physics and Astronomy
29.05.2017 | Earth Sciences