They have found out that the lack or inhibition of the protein it represents decreases the speed at which neoplasias occur, as it prevents the inflammation that contributes to the proliferation of cancer cells. Part of the conclusions of this research work are published in the June edition of the journal 'Cancer Research'.
Experts have used a model of experimental carcinogenesis, that is, have caused cancer in normal experimental mice and also in mice knocked out in that specific gene. After many experiments, they have found out that apart from collaborating to the DNA repair, the parp-1 gene has an influence on the growth of the carcinoma. Moreover, the gene’s lack of expression obstructs the angiogenesis process, which causes the creation of new blood vessels that allow sick cells to survive by receiving nourishment from the host organism.
The novelty of this finding is the possibility of designing new strategies that inhibit protein parp-1 activity in order to stop the progression of cancer. The next step consists of checking in experimentation models the efficacy of inhibitors in the treatment of cancer processes. So far, experts have used molecular medicines to carry out this delay process.
Researchers are trying to find more efficient therapeutical strategies that reinforce the action of antitumoral agents and decrease the administered radiation or chemotherapy doses. This way, the side effects will also decrease.
USA-based scientists have recently proven that this enzyme which repairs sick cells and keeps cell energy could be useful for the treatment of Huntington’s disease and other pathologies characterised by a low level of energy in cells. This is what an article published in the Chemistry & Biologyen’s August edition reveals, written by researchers of the Institute for Neurodegenerative Disease of Massachusetts General Hospital. These experts describe a new inhibitor of polymerase Parp1 which protects the cells affected by the Huntington’s disease in a lab.
Ismael Gaona | alfa
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
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20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
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Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
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10.01.2017 | Event News
09.01.2017 | Event News
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20.01.2017 | Materials Sciences
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