Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Single genetic defect produces specific cognitive deficit in mice

07.09.2006
Researchers have found that, in mice, producing a single genetic defect in a molecule that "reloads" neurons to trigger one another using the neurotransmitter acetylcholine impairs the mice's ability to recognize objects or other mice.

The researchers, Marco Prado, Marc Caron, Vania Prado, and their colleagues, said their findings reveal a critical role in central nervous system (CNS) function for the component of the reloading machinery, called an acetylcholine transporter, that they knocked out.

They also said their findings suggest that the mouse model will be useful in understanding how defects in neurons that use acetylcholine to trigger one another contribute to cognitive decline in such disorders as Alzheimer's disease (AD) and aging. The researchers published their finding in the September 7, 2006, issue of the journal Neuron, published by Cell Press.

To explore the role of the acetylcholine transporter, the researchers genetically modified mice to either completely lack the transporter gene or to have reduced levels of it. Such transporters normally retrieve acetylcholine that one neuron has used to trigger another and transport it to storage sacs called vesicles that are the reservoir for neurotransmitter for subsequent use. The researchers found that such transporter-deficient mice were less able to fill such vesicles with acetylcholine.

In behavioral tests, the researchers found that the mice with lower levels of the transporter were less able to learn to hang on to a rotating rod than normal mice. Mice completely lacking the transporter were totally unable to manage the task because they lacked physical endurance. Thus, wrote the researchers, those mice might be useful models for studying the effects of reduced acetylcholine release in certain neuromuscular disorders.

Both normal mice and those with reduced transporter were equally able to learn and remember to avoid a mild shock. However, the reduced-transporter mice showed deficits in object recognition--significantly less able to remember that they had encountered specific-shaped plastic blocks before. The altered mice also showed less memory of "intruder" mice placed in their cages--evidence of reduced social recognition.

Significantly, the researchers found that when they used a drug to enhance acetylcholine in the transporter-deficient mice, those mice showed improved performance on social recognition tests, implying that the deficit in social recognition was caused by a reduction in "cholinergic tone."

Prado, Caron, and their colleagues concluded that "Our observations support the notion that reduced cholinergic tone in AD mouse models can indeed cause deficits in social memory. However, based on somewhat similar impairments found in the object and social recognition tasks, it is possible that mild cholinergic deficits may cause a more general memory deficit for recognizing previously learned complex cues, whether social or not. Future detailed investigations will be necessary to further define the specific type of cognitive processing affected by cholinergic deficits in these mutants.

"Such studies in mouse models of reduced cholinergic tone may be particularly informative for understanding the contribution of cholinergic decline to specific behavioral alterations observed in certain pathologies of the CNS and may even be helpful in understanding physiological aging," wrote the researchers.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com
http://www.neuron.org

Further reports about: Neuron Recognition acetylcholine cholinergic cognitive deficit

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>