The team is using functional genomic tools to study the nematode worm Caenorhabditis elegans (C. elegans), the first animal species whose genome was completely sequenced and a model organism to study how embryos develop. The study appearing in Current Biology was performed by NYU's Fabio Piano, an assistant professor, and Anita Fernandez, a post-doctoral researcher, at the Center for Comparative Functional Genomics.
Biologists can draw connections between genes based on systematically accumulated experimental evidence. Network diagrams that illustrate such connections show that most genes fall into highly interconnected groups called modules. These modules are often enriched for genes that share the same role. In order to determine the functions of genes whose role is unknown, researchers examine genes in the same module whose function has already been discovered. This approach has proven useful for learning about the roles of unknown genes.
Unlike most genes in the network, mel-28 had connections to two distinct modules. Piano and Fernandez tested the idea that mel-28 plays important roles in both chromosome segregation and nuclear envelope function. Part of this undertaking included examining the protein MEL-28, which the gene mel-28 encodes.
By fusing mel-28 to a gene-encoding GFP, a fluorescent marker, and expressing this fusion in early embryos, they visualized the movement of MEL-28 during cell division in living embryos. Consistent with the idea that MEL-28 had function in chromosome segregation and the nuclear envelope, the MEL-28-GFP fusion was observed to shuttle between the nuclear periphery and the chromosomes during cell division. Additional functional tests showed that mel-28 was essential to both the integrity of the nuclear envelope and to proper chromosome segregation. This study served as a validation of network modeling as a means to identify genes that coordinate multiple functions.
James Devitt | EurekAlert!
Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz
Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences