Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Viral oncoprotein inactivation of p53

A group of scientists led by USC researcher Dr. Xiaojiang Chen lend structural insight into tumor suppressor inactivation by a viral oncoprotein.

Their crystal structure of the large T antigen/p53 complex interaction will be featured on the September 1st cover of G&D (see accompanying image).

The Simian Virus 40 (SV40) genome encodes a large tumor antigen (LTag) protein, which is synthesized early on and is necessary for productive viral infection. Once inside a host cell, LTag interacts with the p53 and Rb tumor suppressor proteins and renders them inactive. p53 and Rb inhibition drives cells into S phase, promoting both host and viral genome replication. Owing to LTag's ability to overtake cellular growth control, and thereby induce tumors in animals, LTag is classified as a viral oncoprotein.

Dr. Chen and colleagues reveal that the LTag-p53 complex is comprised of a hexameric LTag protein bound to six p53 molecules. Their structure illustrates how p53 protein conformation changes upon LTag binding, and thereby prevents p53 binding to DNA.

... more about:
»LTag »oncoprotein »p53

Dr. Chen explains that "The X-ray structure provides a molecular explanation for the oncogenesis potential of the virus oncoprotein LTag. LTag induces the conformational change of p53 protein through physical interactions. By doing so, LTag abolishes the tumor suppressor function of p53, which can lead to genomic instability and tumor formation".

Heather Cosel | EurekAlert!
Further information:

Further reports about: LTag oncoprotein p53

More articles from Life Sciences:

nachricht Sweetening neurotransmitter receptors and other neuronal proteins
28.10.2016 | Max-Planck-Institut für Hirnforschung

nachricht A new look at thyroid diseases
28.10.2016 | Jacobs University Bremen gGmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

A new look at thyroid diseases

28.10.2016 | Life Sciences

Sweetening neurotransmitter receptors and other neuronal proteins

28.10.2016 | Life Sciences

How nanoscience will improve our health and lives in the coming years

27.10.2016 | Materials Sciences

More VideoLinks >>>