The researchers found a new way of measuring the activity of a group of enzymes called DNA topoisomerases that help package DNA, the molecule that stores genetic information, into cells. Chemicals that block these enzymes could be developed into new anti-cancer and anti-bacterial drugs.
The previous method used for measuring the activity of topoisomerases is time consuming and labour-intensive; this new technique is faster, more accurate and could be automated with robotics to screen thousands of chemicals and identify those with the potential to be made into drugs.
“This development is really exciting because it will speed up the whole discovery process for this type of drug. A quicker and more accurate screen will allow more potential drugs to be assessed and therefore aid the search for urgently needed new anti-cancer and antibacterial drugs” says Tony Maxwell. “A patent for the technique has been granted and we already have several pharmaceutical companies that are interested in licensing the technology”.
The technique has been patented and will be marketed by PBL, the technology management company of the John Innes Centre, and will be further developed by Inspiralis Ltd, a spin-out company housed in the Norwich Bioincubator.
The research was funded by the BBSRC and PBL and is published online in the peer-reviewed journal Nucleic Acids Research.
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences