Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tissue microenvironment implicated in susceptibility to liver cancer metastases

15.08.2006
A new research study reports that, in addition to the metastatic potential of tumor cells, a permissive target environment plays a critical role in promoting progression and metastases of liver cancer. The findings, which appear in the August issue of Cancer Cell, published by Cell Press, may lead to strategies for identifying and possibly treating patients that are highly likely to develop metastases.

Hepatocellular carcinoma (HCC) is a liver cancer with an extremely poor prognosis because of its propensity to spread and invade surrounding tissues. Dr. Xin Wei Wang from the National Cancer Institute, Bethesda, Maryland, Dr. Zhao-You Tang from Fudan University, Shanghai, China, and colleagues recently identified a gene expression signature for primary HCC tumor cell specimens that could predict the metastatic potential of HCC in patients with 78% accuracy. To better understand the mechanisms underlying HCC metastases, the researchers went on to examine whether the metastatic propensity of HCC might also be influenced by the microenvironment of the local tissue.

A thorough examination of noncancerous hepatic tissues from two groups of HCC patients, those with and those without detectable metastases, revealed profound differences in gene expression profiles. Specifically, a unique 17 gene expression signature involving genes associated with inflammation and the immune system was identified in patients with the metastatic phenotype. These patients exhibited a global decrease in gene products associated with inflammation and an increase in anti-inflammatory gene products. Importantly, the genetic signature described in this study provided greater than 92% accuracy in predicting metastases, a result that far exceeds the accuracy of the previously described profile based on primary HCC cells.

The researchers also found that the colony-stimulating factor 1 (CSF1) is playing a prominent role in metastasis of liver cancer cells. "The CSF1 may be reprogramming the immune cells to switch from secreting cytokines that create a pro-inflammatory microenvironment to one that is anti-inflammatory--a condition that supports the growth and metastases of liver tumor cells," explains Dr. Wang.

The findings suggest that, in addition to the metastatic potential of the tumor cells themselves, the inflammatory status of the tissues surrounding the tumor cells may play a key role in tumor metastases and progression. "The genetic signature identified in this study is a superior predictive tool to determine HCC metastases and relapse and may have possible utility in clinical settings to identify HCC patients who might benefit from certain postsurgical treatment to prevent metastases and/or recurrence," said Dr. Wang.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com

More articles from Life Sciences:

nachricht Topologische Quantenchemie
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

nachricht Topological Quantum Chemistry
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>