Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Timing of food consumption activates genes in specific brain area

01.08.2006
Giving up your regular late-night snack may be hard, and not just because it's a routine. The habit may genetically change an area of the brain to expect the food at that time, researchers at UT Southwestern Medical Center have discovered.

By training mice to eat at a time when they normally wouldn't, the researchers found that food turns on body-clock genes in a particular area of the brain. Even when the food stopped coming, the genes continued to activate at the expected mealtime.

"This might be an entrance to the whole mysterious arena of how metabolic conditions in an animal can synchronize themselves with a body clock," said Dr. Masashi Yanagisawa, professor of molecular genetics and senior author of the study.

The UT Southwestern researchers report their findings in the Aug. 8 issue of the Proceedings of the National Academy of Sciences.

The daily ups-and-downs of waking, eating and other bodily processes are known as circadian rhythms, which are regulated by many internal and external forces. One class of genes involved in these cycles is known as Period or Per genes.

When food is freely available, the strongest controlling force is light, which sets a body's sleep/wake cycle, among other functions. Light acts on an area in the brain called the suprachiasmatic nucleus, or SCN.

But because destroying the SCN doesn't affect the body clock that paces feeding behavior, the circadian pacemaker for feeding must be somewhere else, Dr. Yanagisawa said.

To find the answer, his group did a simple but labor-intensive experiment. The scientists set the mice on a regular feeding schedule, then examined their brain tissue to find where Per genes were turned on in sync with feeding times.

The researchers put the mice on a 12-hour light/dark cycle, and provided food for four hours in the middle of the light portion.

Because mice normally feed at night, this pattern is similar to humans eating at inappropriate times. Dysfunctional eating patterns play a role in human obesity, particularly in the nocturnal eating often seen in obese people, the researchers note.

The mice soon fell into a pattern of searching for food two hours before each feeding time. They also flipped their normal day/night behavior, ignoring the natural cue that day is their usual time to sleep.

After several days, the researchers found that the daily activation cycle of Per genes in the SCN was not affected by the abnormal feeding pattern.

However, in a few different areas of the brain, particularly a center called the dorsomedial hypothamalic nucleus or DMH, the Per genes turned on strongly in sync with feeding time after seven days.

When the mice subsequently went two days without food, the genes continued to turn on in sync with the expected feeding time.

"They started to show the same pattern of anticipatory behaviors several hours before the previously scheduled time of feeding," said Dr. Yanagisawa, a Howard Hughes Medical Institute investigator. "So somewhere in the body, they clearly remembered this time of day."

Upcoming research will focus on how the centers that control various body clocks communicate with each other, Dr. Yanagisawa said.

Aline McKenzie | EurekAlert!
Further information:
http://www.utsouthwestern.edu

More articles from Life Sciences:

nachricht Warming ponds could accelerate climate change
21.02.2017 | University of Exeter

nachricht An alternative to opioids? Compound from marine snail is potent pain reliever
21.02.2017 | University of Utah

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>