Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Discover Communication Signal for Tissue Development

13.07.2006
Researchers at Rensselaer Polytechnic Institute have discovered a communication signal between cells that plays an important role in cell adhesion and detachment. The finding provides new information about how cells and tissues determine when to let go from surfaces during new growth, according to the researchers.

“Our discovery of this new signaling pathway adds to fundamental information about how cells work together during the remodeling of tissues and organs,” said Andrea Page-McCaw, assistant professor of biology at Rensselaer. “This finding also may provide clues about the basic mechanisms of inflammation and wound healing in vertebrates.”

Page-McCaw’s laboratory studies the fruit fly as a model system to better understand a group of genetic enzymes called matrix metalloproteinases (MMPs). Fruit flies have two distinct MMPs, compared to 22 such enzymes found in humans and mice. In previous work, Page-McCaw found that both MMPs present in fruit flies are critical to their survival.

“Although MMP enzymes have been linked to disease progression, their normal function is to help in tissue growth and wound healing,” Page-McCaw said. “MMP research eventually could lead to therapeutics for a range of illnesses, including cancer and arthritis.”

Page-McCaw studies development and remodeling of the airway system, or tracheae, in fruit fly larvae with normal and mutant MMPs to determine how those genes contribute to normal function. In this work, she and her colleagues found that one of the MMPs chops off a piece of a protein called Ninjurin A, which is located at the surfaces of cells. The liberated piece of Ninjurin A protein then signals to other cells that it is time to detach from their surface, both in isolated cells grown in culture and in whole flies. When tracheal cells fail to detach from the insect exoskeleton, the tracheae do not grow properly and break.

The findings are currently available online in advance of print publication July 15 by the journal Genes & Development. The paper is titled “An MMP Liberates the Ninjurin A Ectodomain to Signal a Loss of Cell Adhesion.”

The research is led by Page-McCaw and includes Shuning Zhang, doctoral student at Rensselaer, and Bernadette Glasheen and Gyna Sroga, research specialists at Rensselaer. This work was initiated by Page-McCaw during her fellowship at the University of California at Berkeley, where she was assisted by Gina Dailey and Elaine Kwan.

Biotechnology and Interdisciplinary Studies at Rensselaer

At Rensselaer, faculty and students in diverse academic and research disciplines are collaborating at the intersection of the life sciences and engineering to encourage discovery and innovation. Rensselaer’s four biotechnology research constellations - biocatalysis and metabolic engineering, functional tissue engineering and regenerative medicine, biocomputation and bioinformatics, and integrative systems biology - engage a multidisciplinary mix of faculty and students focused on the application of engineering and physical and information sciences to the life sciences. Ranked among the world’s most advanced research facilities, Rensselaer’s Center for Biotechnology and Interdisciplinary Studies provides a state-of-the-art platform for collaborative research and world-class programs and symposia.

About Rensselaer

Rensselaer Polytechnic Institute, founded in 1824, is the nation’s oldest technological university. The university offers bachelor’s, master’s, and doctoral degrees in engineering, the sciences, information technology, architecture, management, and the humanities and social sciences. Institute programs serve undergraduates, graduate students, and working professionals around the world. Rensselaer faculty are known for pre-eminence in research conducted in a wide range of fields, with particular emphasis in biotechnology, nanotechnology, information technology, and the media arts and technology. The Institute is well known for its success in the transfer of technology from the laboratory to the marketplace so that new discoveries and inventions benefit human life, protect the environment, and strengthen economic development.

Tiffany Lohwater | EurekAlert!
Further information:
http://www.rpi.edu

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>