Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

In search of new radioprotectors

07.07.2006
Unique drugs that are able to protect human organisms from ionizing radiation action are being developed by specialists of the Federal State Unitary Enterprise “Russian Federal Nuclear Center – All-Russian Scientific Research of Experimental Physics” (Sarov) and their colleagues, chemists of the Lomonosov State University (Moscow) and the St. Petersburg Chemical-Pharmaceutical Academy.

Researchers have already discovered compounds, radioprotective characteristics of which, at lower toxicity, exceed all compounds known so far. However, investigations have not been finished yet. The search for new radioprotectors (effective, innocuous and low-cost ones), as well as compounds that increase radio-therapy efficiency for cancer treatment, is going on. Information about this very important development was placed by the ISTC experts on the International Science and Technology Center’s site, in the advanced research section.

Generally, many countries of the world are searching compounds that are able to protect human beings and animals from ionizing radiation. However, the results of this effort remain pretty moderate. Known substances that are potentially suitable for practical use are few and none of them meets all requirements to drugs.

“Even the most efficient radioprotectors from well-known ones, - explains project manager, I. Korzeneva, Ph.D. (Biology), - for example, cystamine (the substance used for treatment of acute radiation sickness) either did not protect sufficiently from exposure to radiation or were too toxic. Besides, in the majority of cases, these drugs possess prophylactic (introduction prior to irradiation), but not therapeutic (introduction after irradiation) action. We suggest that the range of compounds should be extended, among which we hope to find not only efficient radioprotectors with prophylactic, therapeutic and immunomodulatory action, but also radiation sensitizers reinforcing ionizing radiation of tumor cells. We expect that new drugs will possess high bioavailability and low toxicity, and it will be possible to perform their synthesis based on domestic raw materials, and this will tell upon cost.”

It should be noted that researchers’ assurance is fully justified. Now, the authors have already managed to synthesize compounds, radioprotective properties of which are much higher than those of cystamine, active leucostimulators and antineoplastic drugs. Experiments have proved that these substances protect from death irradiated laboratory animals or extend their lifetime. Besides, the researchers have synthesized new immunomodulators, antioxidants and antihypoxic agents, which are similar or more efficient as compared to the known ones.

The researchers’ short-term plans are as follows: to discover several most promising drugs and to develop quick, efficient, low-stage and low-cost methods of their synthesis. It is also necessary to make the required amount of drugs for preclinical trials. To minimize time and effort spent on search of new compounds with predetermined properties, the authors are planning to engage computer simulation techniques.

Thus, in case of proper funding, drugs for protection of staff of nuclear power-stations, radioactive waste processing enterprises, and eventually, cosmonauts, will be not only developed but also synthesized likewise drugs for radio-therapy of oncological diseases, which are able to fight against malignant cells without injuring healthy cells.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>