Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

In search of new radioprotectors

07.07.2006
Unique drugs that are able to protect human organisms from ionizing radiation action are being developed by specialists of the Federal State Unitary Enterprise “Russian Federal Nuclear Center – All-Russian Scientific Research of Experimental Physics” (Sarov) and their colleagues, chemists of the Lomonosov State University (Moscow) and the St. Petersburg Chemical-Pharmaceutical Academy.

Researchers have already discovered compounds, radioprotective characteristics of which, at lower toxicity, exceed all compounds known so far. However, investigations have not been finished yet. The search for new radioprotectors (effective, innocuous and low-cost ones), as well as compounds that increase radio-therapy efficiency for cancer treatment, is going on. Information about this very important development was placed by the ISTC experts on the International Science and Technology Center’s site, in the advanced research section.

Generally, many countries of the world are searching compounds that are able to protect human beings and animals from ionizing radiation. However, the results of this effort remain pretty moderate. Known substances that are potentially suitable for practical use are few and none of them meets all requirements to drugs.

“Even the most efficient radioprotectors from well-known ones, - explains project manager, I. Korzeneva, Ph.D. (Biology), - for example, cystamine (the substance used for treatment of acute radiation sickness) either did not protect sufficiently from exposure to radiation or were too toxic. Besides, in the majority of cases, these drugs possess prophylactic (introduction prior to irradiation), but not therapeutic (introduction after irradiation) action. We suggest that the range of compounds should be extended, among which we hope to find not only efficient radioprotectors with prophylactic, therapeutic and immunomodulatory action, but also radiation sensitizers reinforcing ionizing radiation of tumor cells. We expect that new drugs will possess high bioavailability and low toxicity, and it will be possible to perform their synthesis based on domestic raw materials, and this will tell upon cost.”

It should be noted that researchers’ assurance is fully justified. Now, the authors have already managed to synthesize compounds, radioprotective properties of which are much higher than those of cystamine, active leucostimulators and antineoplastic drugs. Experiments have proved that these substances protect from death irradiated laboratory animals or extend their lifetime. Besides, the researchers have synthesized new immunomodulators, antioxidants and antihypoxic agents, which are similar or more efficient as compared to the known ones.

The researchers’ short-term plans are as follows: to discover several most promising drugs and to develop quick, efficient, low-stage and low-cost methods of their synthesis. It is also necessary to make the required amount of drugs for preclinical trials. To minimize time and effort spent on search of new compounds with predetermined properties, the authors are planning to engage computer simulation techniques.

Thus, in case of proper funding, drugs for protection of staff of nuclear power-stations, radioactive waste processing enterprises, and eventually, cosmonauts, will be not only developed but also synthesized likewise drugs for radio-therapy of oncological diseases, which are able to fight against malignant cells without injuring healthy cells.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

More articles from Life Sciences:

nachricht Bolstering fat cells offers potential new leukemia treatment
17.10.2017 | McMaster University

nachricht Ocean atmosphere rife with microbes
17.10.2017 | King Abdullah University of Science & Technology (KAUST)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>