Researchers have already discovered compounds, radioprotective characteristics of which, at lower toxicity, exceed all compounds known so far. However, investigations have not been finished yet. The search for new radioprotectors (effective, innocuous and low-cost ones), as well as compounds that increase radio-therapy efficiency for cancer treatment, is going on. Information about this very important development was placed by the ISTC experts on the International Science and Technology Center’s site, in the advanced research section.
Generally, many countries of the world are searching compounds that are able to protect human beings and animals from ionizing radiation. However, the results of this effort remain pretty moderate. Known substances that are potentially suitable for practical use are few and none of them meets all requirements to drugs.
“Even the most efficient radioprotectors from well-known ones, - explains project manager, I. Korzeneva, Ph.D. (Biology), - for example, cystamine (the substance used for treatment of acute radiation sickness) either did not protect sufficiently from exposure to radiation or were too toxic. Besides, in the majority of cases, these drugs possess prophylactic (introduction prior to irradiation), but not therapeutic (introduction after irradiation) action. We suggest that the range of compounds should be extended, among which we hope to find not only efficient radioprotectors with prophylactic, therapeutic and immunomodulatory action, but also radiation sensitizers reinforcing ionizing radiation of tumor cells. We expect that new drugs will possess high bioavailability and low toxicity, and it will be possible to perform their synthesis based on domestic raw materials, and this will tell upon cost.”
It should be noted that researchers’ assurance is fully justified. Now, the authors have already managed to synthesize compounds, radioprotective properties of which are much higher than those of cystamine, active leucostimulators and antineoplastic drugs. Experiments have proved that these substances protect from death irradiated laboratory animals or extend their lifetime. Besides, the researchers have synthesized new immunomodulators, antioxidants and antihypoxic agents, which are similar or more efficient as compared to the known ones.
The researchers’ short-term plans are as follows: to discover several most promising drugs and to develop quick, efficient, low-stage and low-cost methods of their synthesis. It is also necessary to make the required amount of drugs for preclinical trials. To minimize time and effort spent on search of new compounds with predetermined properties, the authors are planning to engage computer simulation techniques.
Thus, in case of proper funding, drugs for protection of staff of nuclear power-stations, radioactive waste processing enterprises, and eventually, cosmonauts, will be not only developed but also synthesized likewise drugs for radio-therapy of oncological diseases, which are able to fight against malignant cells without injuring healthy cells.
Nadezda Markina | alfa
Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel
Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
27.04.2017 | Health and Medicine
27.04.2017 | Information Technology
26.04.2017 | Materials Sciences