Researchers have already discovered compounds, radioprotective characteristics of which, at lower toxicity, exceed all compounds known so far. However, investigations have not been finished yet. The search for new radioprotectors (effective, innocuous and low-cost ones), as well as compounds that increase radio-therapy efficiency for cancer treatment, is going on. Information about this very important development was placed by the ISTC experts on the International Science and Technology Center’s site, in the advanced research section.
Generally, many countries of the world are searching compounds that are able to protect human beings and animals from ionizing radiation. However, the results of this effort remain pretty moderate. Known substances that are potentially suitable for practical use are few and none of them meets all requirements to drugs.
“Even the most efficient radioprotectors from well-known ones, - explains project manager, I. Korzeneva, Ph.D. (Biology), - for example, cystamine (the substance used for treatment of acute radiation sickness) either did not protect sufficiently from exposure to radiation or were too toxic. Besides, in the majority of cases, these drugs possess prophylactic (introduction prior to irradiation), but not therapeutic (introduction after irradiation) action. We suggest that the range of compounds should be extended, among which we hope to find not only efficient radioprotectors with prophylactic, therapeutic and immunomodulatory action, but also radiation sensitizers reinforcing ionizing radiation of tumor cells. We expect that new drugs will possess high bioavailability and low toxicity, and it will be possible to perform their synthesis based on domestic raw materials, and this will tell upon cost.”
It should be noted that researchers’ assurance is fully justified. Now, the authors have already managed to synthesize compounds, radioprotective properties of which are much higher than those of cystamine, active leucostimulators and antineoplastic drugs. Experiments have proved that these substances protect from death irradiated laboratory animals or extend their lifetime. Besides, the researchers have synthesized new immunomodulators, antioxidants and antihypoxic agents, which are similar or more efficient as compared to the known ones.
The researchers’ short-term plans are as follows: to discover several most promising drugs and to develop quick, efficient, low-stage and low-cost methods of their synthesis. It is also necessary to make the required amount of drugs for preclinical trials. To minimize time and effort spent on search of new compounds with predetermined properties, the authors are planning to engage computer simulation techniques.
Thus, in case of proper funding, drugs for protection of staff of nuclear power-stations, radioactive waste processing enterprises, and eventually, cosmonauts, will be not only developed but also synthesized likewise drugs for radio-therapy of oncological diseases, which are able to fight against malignant cells without injuring healthy cells.
Nadezda Markina | alfa
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy