Dr Tomo Tanaka, Professor Julian Blow and their team member Dr Etsushi Kitamura at the University’s School of Life Sciences, discovered that, contrary to conventional views, the machinery that copies DNA stays fixed inside the cell whilst the DNA being copied has to move.
DNA is a string-like material found in our cells, which encodes all our genetic information. For the genetic information to be properly inherited, a cell must copy its DNA using a specialized copying machine before it can divide into two daughter cells. It was originally thought that the DNA copying machine moves along the DNA as it is copied.
Dr Tomo Tanaka says “We can liken the process that we have discovered in cells to an assembly line for making cars, invented by Henry Ford and his engineers. It was a revolutionary idea in industry that products move along a line and engineers stay at fixed places to assemble them. This achieved much more accuracy and efficiency in manufacturing products.”
“Similarly cells can copy DNA accurately and efficiently by moving it through a stationary copying machine, rather than by moving the copying machinery along stationary DNA. Because errors in DNA copying cause human diseases such as cancers, it is crucial to understand how our cells organize the copying of DNA in space and time”.
Dr Tomo Tanaka and Professor Julian Blow are Principal Investigators in the Division of Gene Regulation and Expression in School of Life Sciences at the University of Dundee.
Professor Angus Lamond, Head of the Division of Gene Regulation and Expression said “Cancer is a disease caused by cells dividing and multiplying out of control. This latest advance is a wonderful example of how genetic research in Dundee is leading the way in understanding how cells divide and therefore helps us understand the basic causes of cancer. Future cancer treatments will build upon this improved understanding of what has gone wrong."
Roddy Isles | alfa
Making fuel out of thick air
08.12.2017 | DOE/Argonne National Laboratory
‘Spying’ on the hidden geometry of complex networks through machine intelligence
08.12.2017 | Technische Universität Dresden
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
08.12.2017 | Event News
07.12.2017 | Event News
05.12.2017 | Event News
08.12.2017 | Life Sciences
08.12.2017 | Information Technology
08.12.2017 | Information Technology