Dr Tomo Tanaka, Professor Julian Blow and their team member Dr Etsushi Kitamura at the University’s School of Life Sciences, discovered that, contrary to conventional views, the machinery that copies DNA stays fixed inside the cell whilst the DNA being copied has to move.
DNA is a string-like material found in our cells, which encodes all our genetic information. For the genetic information to be properly inherited, a cell must copy its DNA using a specialized copying machine before it can divide into two daughter cells. It was originally thought that the DNA copying machine moves along the DNA as it is copied.
Dr Tomo Tanaka says “We can liken the process that we have discovered in cells to an assembly line for making cars, invented by Henry Ford and his engineers. It was a revolutionary idea in industry that products move along a line and engineers stay at fixed places to assemble them. This achieved much more accuracy and efficiency in manufacturing products.”
“Similarly cells can copy DNA accurately and efficiently by moving it through a stationary copying machine, rather than by moving the copying machinery along stationary DNA. Because errors in DNA copying cause human diseases such as cancers, it is crucial to understand how our cells organize the copying of DNA in space and time”.
Dr Tomo Tanaka and Professor Julian Blow are Principal Investigators in the Division of Gene Regulation and Expression in School of Life Sciences at the University of Dundee.
Professor Angus Lamond, Head of the Division of Gene Regulation and Expression said “Cancer is a disease caused by cells dividing and multiplying out of control. This latest advance is a wonderful example of how genetic research in Dundee is leading the way in understanding how cells divide and therefore helps us understand the basic causes of cancer. Future cancer treatments will build upon this improved understanding of what has gone wrong."
Roddy Isles | alfa
Modern genetic sequencing tools give clearer picture of how corals are related
17.08.2017 | University of Washington
The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
17.08.2017 | Physics and Astronomy
17.08.2017 | Materials Sciences
17.08.2017 | Materials Sciences