Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The long and the short of it: Expanding small RNA biology in mammals

12.06.2006
In independent studies, Drs. Haifan Lin (Duke University) and Toshiaki Watanabe (Kyoto University) and colleagues report on their identification of novel small RNAs in the mouse germline.

"The discovery of piRNAs reveals a new dimension of the small RNA world. The complexity of piRNAs and their correspondence to different types genomic sequences implicates their potentially diverse functions. This is another gold mine for studying gene regulation, especially that related to reproduction and inheritance," explains Dr. Lin.

Their papers will be available online (www.genesdev.org) ahead of the scheduled July 1st publication date.

While hundreds of small RNAs have been isolated from somatic tissues in mammals, these papers are representative of a number of recent and up-and-coming studies independently identifying unique small RNAs residing in the mouse germline. The newly identified piRNAs are bigger in size (26-31 nucleotides long) than most previously described small RNAs in mammals, and are shown to be associated with the piwi subfamily of the Argonaute protein family. They are largely expressed in the mouse testes, and are thought to play a role in spermatogenesis.

Future research will be aimed at elucidating the pathway of biogenesis of these novel, small RNAs, as well as the targets and function of this emerging class of molecules. Dr.Watanabe emphasizes that "Newly identified small RNAs have features clearly different from those of previously identified small RNAs such as miRNAs or siRNAs. The sequences of this novel small RNAs are not conserved between species. However, interestingly, the presence of this novel class of small RNAs is conserved among diverse animals including humans."

Heather Cosel | EurekAlert!
Further information:
http://www.cshl.edu
http://www.genesdev.org

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>