Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New method for targeting cancer cells

07.06.2006
‘LEGO-Like’ Building Blocks to Halt Cell Growth Wins Kaye Prize for Hebrew University Ph.D. Student

A method for delivery of drugs to targeted cells through the design of specific molecular structures called SIB (Small Integrated Building Blocks) has won a prestigious scientific prize for a Ph.D. student in organic chemistry at the Hebrew University of Jerusalem.

Jerusalemite Nir Qvit, 34, will be one of those receiving the Kaye Innovation Award on June 13, during the 69th meeting of the Hebrew university Board of Governors.

Qvit has shown through his research that it is possible to greatly increase drug delivery efficiency by designing specific molecular structures made up of known pharmaceutically effective peptides (small protein molecules) that are attached to tailor-made, geometric-like structures called “scaffolding.”

Each scaffold is specifically designed to combine the peptides in such a way that they will form an effective medicinal combination and so that they will bind to the receptors of specific targeted cells. Qvit refers to his process as somewhat analogous to building different kinds of structures through the use of LEGO.

Qvit, a student of Prof. Chaim Gilon of the Department of Organic Chemistry, has shown, for example, that with a particular combination of peptides and scaffold design, it is possible to create a synthetic molecule that will bind to the IGF-1 (insulin-like growth factor-1) receptor. IGF-1 is a protein that plays a critical role in the proliferation of many cancers, including prostate, lung, breast, colon and brain cancers. The binding action of the molecule to the receptor inhibits the activation of the IGF-1 protein in the cells, thus halting the cancerous growth.

Through this process of “combinational chemistry,” involving peptides and scaffold design, Qvit says that many different types of molecules can be built that will reach specifically targeted cells, offering hope for treatment of not only cancer, but other diseases as well, without harming healthy cells.

The Kaye Innovation Awards have been given annually since 1994. Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff, and students of the Hebrew University to develop innovative methods and inventions with good commercial potential which will benefit the university and society.

Jerry Barach | The Hebrew University of Jerusal
Further information:
http://www.huji.ac.il

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>