The findings raise the question of whether genetic variations in specific proteins in humans may protect some people from age associated diseases, while placing others at heightened risk of cancer.
In the study, which received funding from the UK’s Biotechnology and Biological Sciences Research Council (BBSRC), researchers genetically removed checkpoint proteins in the nematode worm, C.elegans, which resulted in a 15 to 30 per cent increase in the lifespan of the worms.
Previously it was thought that checkpoint proteins were only functional in dividing cells, but this new research suggests they have a dual function, also being active in cells that no longer divide.
Gordon Lithgow, Associate Professor at the Buck Institute, explained: “We know that ageing is a huge risk factor in cancer, and although we know the role these proteins plays in preventing cancer – or encouraging it if the proteins are not working properly - we did not imagine that this checkpoint protein would be involved in determining lifespan.”
The team of international researchers, including scientists from Denmark and India, discovered the dual role of the checkpoint proteins while screening the worms for genes that determine stress resistance and longevity in cells.
Professor Lithgow said: “We have known for a long time that checkpoint proteins can influence the development of cancer, now we know they can influence longevity too. This discovery has exciting potential as an area of inquiry into a possible cellular link between ageing and cancer. We are now concentrating on trying to identify additional tumour suppressor genes that impact on ageing in worms and human cells. We think there are many more checkpoint proteins some of which may help to develop therapies for cancer and age associated diseases.”
Professor Julia Goodfellow, Chief Executive of BBSRC, which funded the initial stages of the research, said: “Ageing and cancer are global concerns and it is exciting to see the success of international collaborations such as this. It is only by understanding fundamental bioscience like this that we can develop and deliver health benefits to the public in the future.”
Matt Goode | alfa
Tag it EASI – a new method for accurate protein analysis
20.06.2018 | Max-Planck-Institut für Biochemie
How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
20.06.2018 | Materials Sciences
20.06.2018 | Information Technology
20.06.2018 | Information Technology