Bacteria mate using a timely protruding phallus.
Mammalian cells rarely take bacteria up on their offer of DNA.
Bacteria caught mating with mammalian cells.
Cross-species coupling is generally frowned upon. But in the liberal labs of California it is actively being encouraged. Bugs that are persuaded to get down and dirty with hamster cells are rewriting sex manuals in the act.
Like humans, bacteria mate using a timely protruding phallus. It suckers a nearby bacterium and drags it close enough to shoot in DNA - a process called conjugation.
Waters hopes to exploit bacteria’s wanton ways for gene therapy - the transfer of healthy genes into human cells to compensate for defective ones causing disease. In the lungs, for example, resident bacteria could be modified to carry and transfer genes such as the one that is faulty in the lung disease cystic fibrosis.
"It could be a powerful way to deliver DNA," agrees Ghigo. Large populations of bacteria constantly attempting sex might have more success than a single dose of another gene-delivery drug.
Gene-therapy researcher Stephen Hyde at the University of Oxford, UK, is more doubtful. Thick protective mucous might stop the bacteria getting close to lung cells, he points out. Introducing bacteria into the body and transferring unwanted bacterial genes might also be risks.
In the lab, conjugation could be a way to transfer large pieces of DNA into mammalian cells. Such transfers are currently difficult, says Hyde, as the DNA tends to break easily.
Conjugation was first reported in 1946, winning its voyeur, Joshua Lederberg, a Nobel prize. The plasmid that carries the genes responsible was named the fertility factor.
The transfer of circular DNA always starts at a defined point. By interrupting mating bugs at regular intervals, geneticists were able to work out which genes had been passed over. Hence the first map of the E.coli chromosome was measured in minutes rather than megabases.
HELEN PEARSON | Nature News Service
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Second research flight into zero gravity
21.10.2016 | Universität Zürich
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences