If the chemistry is right … you might remember this
A young Australian scientist has made an important discovery about how brain cells communicate. This finding is central to understanding all brain function – from laying down memory to being able to walk
The groundbreaking research has been published in the latest edition of world-leading journal Nature Neuroscience.
Victor Anggono, a PhD student at the Children’s Medical Research Institute (CMRI), set out to identify the molecular partners of a key protein called dynamin, and how their partnership allows neurons to send messages .
The result was astounding. A protein called syndapin, previously thought to have no major role in nerve communication, was proven to be the molecule that simultaneously works with dynamin to allow the transmission of messages between nerve cells.
The brain functions by sending chemical messages between nerves. The messages, or neurotranmsitters, are held in tiny packages at the nerve terminal where they are released to send a signal. The packages then return to the cell and are re-filled so that brain function can continue.
In collaboration with researchers from the University of Edinburgh further studies have revealed that by blocking the interaction of these two proteins nerve communication shuts down.
’The partnership between dynamin and syndapin is crucial for the continous cycle of neurotransmission. This makes syndpain a very specific target for medicines that could treat conditions where there is an overload of nerve activity, such as during a seizures,’ said Dr Phil Robinson leader of the research at the CMRI.
The relationship between dynamin and syndapin is also crucial to understanding other processes where there is a high level of brain activity and nerve transmission, such as when forming memories and during learning.
Dr Robinson says, ’A discovery like this will be vital for future research into many neurological disorders, such as epilepsy, conditions of memory loss and schizophrenia. It is only through research like this, that medical science can now target specific problems and develop improved treatments.’
Dr Phillip Robinson | EurekAlert!
Closing in on advanced prostate cancer
13.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)
Visualizing single molecules in whole cells with a new spin
13.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
13.12.2017 | Health and Medicine
13.12.2017 | Physics and Astronomy
13.12.2017 | Life Sciences