Dr Jonathan Chubb, Principal Investigator in the Division of Cell and Developmental Biology in the School of Life Sciences at the University of Dundee, in collaboration with researchers in New York, has made a major advance in our understanding of gene function, as reported in the new issue of the journal "Current Biology" on 23rd May.
After several decades of experimentation demonstrating the importance of gene action to human diseases and normal bodily function, this new advance allows researchers, for the first time, to directly watch the behaviour of a single gene.
Genes must operate at specific times and in specific parts of our bodies, to achieve normal bodily function. When genes do not operate in the correct part of the body or fail to operate at the correct time, this can cause diseases. Cancer is one of the many diseases resulting from improper gene function.
Using an extremely powerful microscope to look inside living cells, Dr Chubb and his colleagues were able to observe a single gene as it turned on and off.
The picture (also attached) shows a movie of a gene turning on and off. The movie is of a cell and in some frames the cell has a bright spot. Chubb and his co-workers used a fluorescent marker that sticks to the gene only when it is active. Under a microscope, this fluorescent marker appears as a spot. The spot is present, then disappears, then appears again.
Dr Chubb likens a gene to a thermostat: "The central heating in a home is not on all the time- that would be inefficient and would overheat the house. The solution is to have a thermostat, which injects a little bit of heat when it is required then turns off again. The cell is similar- it needs the gene to be turned on, but too much activity at the wrong time can be a problem, so the solution is to have small bursts of activity."
The researchers believe that their technique will be a powerful new method for understanding how genes misbehave in human diseases, such as cancer and Alzheimers. The ability to watch a cell as it decides to activate or inactivate a gene will provide unrivalled insight into how this process goes wrong in these and other diseases.
Dr Chubb’s research is funded by the Medical Research Council and his collaborators by the National Institutes of Health (NIH), USA. Dr Chubb took up his position in the School of Life Sciences in October 2005 having arrived from the Albert Einstein College of Medicine, New York, USA.
Roddy Isles | alfa
Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main
Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
24.05.2018 | Ecology, The Environment and Conservation
24.05.2018 | Medical Engineering
24.05.2018 | Physics and Astronomy