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First characterization of chikungunya viruses from Indian Ocean outbreak

Since late 2004, a large outbreak of chikungunya fever in the Indian Ocean has caused a public health crisis and alarmed international experts. A team of scientists led by Sylvain Brisse (of the Pasteur Institute) now reports the first molecular data on the viruses involved in the outbreak in the international open-access journal PLoS Medicine.

The outbreak affects the populations of Comoros, Mayotte, Madagascar, Mauritius, Seychelles, and Réunion. It is much larger than any previous outbreak, with up to one third of the populations of those islands (several hundred thousand people) infected. More recently, several states of India have also reported cases of the disease.

The disease is caused by the chikungunya virus, which is spread to humans by mosquito bites. It was first described in Tanzania in 1952 and has since been found in Africa, India, and South East Asia. The name is derived from a local Tanzanian word meaning "that which bends up", a reference to the stooped posture many patients develop as a result of painful inflammation of the joints commonly associated with the disease. Other symptoms of the disease include fever, headache, and a skin rash. There is no specific treatment available. Most patients get better after a few days, but the pain in the joints can persist for long after the other symptoms have disappeared.

Brisse and colleagues determined the entire genetic sequence of six virus samples isolated from patients in different places (five from Réunion and one from the Seychelles) and different times (three from early 2005 and three from later in 2005) during the outbreak. They also sequenced one of the viral genes (called E1) from virus samples taken from an additional 121 patients. The results show that the outbreak began with a strain related to East-African strains of the virus which subsequently developed into several distinct variants. All of the Indian Ocean sequences share unique molecular features that differ from strains of the virus involved in earlier outbreaks and suggest how the virus could have become more "aggressive". Experiments are now underway to test which of these features might be responsible for the apparent increase in the virus’ ability to infect humans and cause disease.

As the authors note, the mosquitoes that transmit the Chikungunya virus in Africa and Asia are not limited to these areas--in fact they are the same ones that transmit yellow fever and dengue fever in many parts of the world--which raises the possibility that the chikungunya virus could spread and cause disease elsewhere.

Andrew Hyde | EurekAlert!
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