Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

First characterization of chikungunya viruses from Indian Ocean outbreak

23.05.2006
Since late 2004, a large outbreak of chikungunya fever in the Indian Ocean has caused a public health crisis and alarmed international experts. A team of scientists led by Sylvain Brisse (of the Pasteur Institute) now reports the first molecular data on the viruses involved in the outbreak in the international open-access journal PLoS Medicine.

The outbreak affects the populations of Comoros, Mayotte, Madagascar, Mauritius, Seychelles, and Réunion. It is much larger than any previous outbreak, with up to one third of the populations of those islands (several hundred thousand people) infected. More recently, several states of India have also reported cases of the disease.

The disease is caused by the chikungunya virus, which is spread to humans by mosquito bites. It was first described in Tanzania in 1952 and has since been found in Africa, India, and South East Asia. The name is derived from a local Tanzanian word meaning "that which bends up", a reference to the stooped posture many patients develop as a result of painful inflammation of the joints commonly associated with the disease. Other symptoms of the disease include fever, headache, and a skin rash. There is no specific treatment available. Most patients get better after a few days, but the pain in the joints can persist for long after the other symptoms have disappeared.

Brisse and colleagues determined the entire genetic sequence of six virus samples isolated from patients in different places (five from Réunion and one from the Seychelles) and different times (three from early 2005 and three from later in 2005) during the outbreak. They also sequenced one of the viral genes (called E1) from virus samples taken from an additional 121 patients. The results show that the outbreak began with a strain related to East-African strains of the virus which subsequently developed into several distinct variants. All of the Indian Ocean sequences share unique molecular features that differ from strains of the virus involved in earlier outbreaks and suggest how the virus could have become more "aggressive". Experiments are now underway to test which of these features might be responsible for the apparent increase in the virus’ ability to infect humans and cause disease.

As the authors note, the mosquitoes that transmit the Chikungunya virus in Africa and Asia are not limited to these areas--in fact they are the same ones that transmit yellow fever and dengue fever in many parts of the world--which raises the possibility that the chikungunya virus could spread and cause disease elsewhere.

Andrew Hyde | EurekAlert!
Further information:
http://www.plos.org
http://dx.doi.org/10.1371/journal.pmed.0030263

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>