Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers uncover new mechanism of tumor suppressor

23.05.2006
Findings to be published in the journal Nature

Researchers from the University of Colorado-Denver and Health Sciences Center and Stanford University have discovered a molecular mechanism that explains how cells respond to DNA damage and other acute stresses, and if disrupted can cause cancer. Their findings, which could lead to new diagnostic markers and cancer treatments with fewer side effects, will appear in two reports in the May 21 advanced online version of the journal Nature.

The studies, led by Tatiana Kutateladze, PhD, an assistant professor in the UCDHSC Department of Pharmacology, and Or Gozani, MD, PhD, an assistant professor in the Department of Biological Sciences at Stanford University, revealed the significance of a novel function of the recently discovered tumor-suppressive molecule, which is thought to inhibit cancer formation and growth. These findings highlight a new mechanism to regulate gene expression programs that allow for appropriate responses to DNA damage in normal cells. When the process breaks down, such damage and other acute stresses are thought to lead to cancer.

The first study, Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2, was conducted in Kutateladze’s laboratory with the assistance of graduate student Pedro Peña and research assistant Foteini Davrazou. Other co-authors include Rui Zhao, PhD, an assistant professor in the UCDHSC Department of Biochemistry and Molecular Genetics; Or Gozani, Xiaobing Shi and Kay L. Walter from Stanford University’s Department of Biological Sciences; and Vladislav V. Verkhusha from the Department of Anatomy and Structural Biology at the Albert Einstein College of Medicine in New York.

The paper based on their work describes the structural aspects of the tumor suppressor action, while functional studies were accomplished by Gozani’s group, and are the subject of the second report that will appear in Nature titled ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.

"Our findings have established the mechanistic principles by which the inhibitor of growth 2 tumor suppressor recognizes chromatin and regulates cell growth, proliferation, stress responses and aging. We hope this discovery opens up new opportunities to establish novel targets to prevent and treat cancer," said Kutateladze, a NARSAD Young Investigator and an American Cancer Society Research Scholar.

Research in Kutateladze’s laboratory focuses on molecular mechanisms underlying signaling and regulation by chromatin- and lipid-binding biomolecules implicated in cancer and other human diseases. She employs high field Nuclear Magnetic Resonance spectroscopy, X-ray crystallography and other biochemical and biophysical approaches to elucidate three-dimensional atomic-resolution structures and dynamics of proteins to better understand their physiological functions and relevance to diseases.

Mark Shwartz | EurekAlert!
Further information:
http://www.stanford.edu
http://www.nature.com

More articles from Life Sciences:

nachricht Modern genetic sequencing tools give clearer picture of how corals are related
17.08.2017 | University of Washington

nachricht The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Gold shines through properties of nano biosensors

17.08.2017 | Physics and Astronomy

Greenland ice flow likely to speed up: New data assert glaciers move over sediment, which gets more slippery as it gets wetter

17.08.2017 | Earth Sciences

Mars 2020 mission to use smart methods to seek signs of past life

17.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>