Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Viral hitchhiker inhibits Wolbachia bacteria’s ability to proliferate

19.05.2006
New MBL study results may aid battle against insect-borne diseases

Scientists studying the widespread symbiotic bacteria Wolbachia have long been interested in its ability to proliferate. One way it does this is by hijacking sperm of its insect hosts and genetically tricking them to bear more infected females, the only sex that transmits the bacteria. Now, a new study from the MBL (Marine Biological Laboratory), published in the May 18 issue of PLoS Pathogens, demonstrates that a virus common to Wolbachia cells may be a key inhibitor of the cellular process that allows Wolbachia to manipulate insect reproduction.

Because Wolbachia are found in about 75 percent of the world’s insects, the discovery could impact the development of virally delivered biocontrol tools for insects that transmit pathogens to humans or harm agriculture. It might also enable the design of alternative therapies for debilitating illnesses such as river blindness and elephantiasis, whose pathologies are caused by Wolbachia bacteria living in the parasitic worms associated with these diseases.

The new research, led by Seth Bordenstein, an Assistant Scientist in the MBL’s Program in Global Infectious Diseases, shows that a virus known as WO-B interferes with Wolbachia’s ability to cause cytoplasmic incompatibility, the reproductive manipulation of its insect host.

Until now, scientists believed the virus was somehow inducing this process. But viruses pirate cells to reproduce, often killing the cells as a result. So Bordenstein and his colleagues hypothesized that by preying on Wolbachia cells, the WO-B virus might reduce the incidence of cytoplasmic incompatibility in a host, not promote it.

Using DNA analysis and electron microscopy, the scientists quantified the number of WO-B viruses and Wolbachia cells in the testes of a common host: the fruit-fly-sized jewel wasp, Nasonia vitripennis. The researchers found that the virus was indeed associated with reduced bacterial growth. Then they bred the wasps and confirmed fewer incidences of cytoplasmic incompatibility in relation to the reduced presence of the bacteria and increased presence of the virus.

"We’re excited about these findings because there is a great deal of interest in deciphering the genetic and cytological mechanisms of cytoplasmic incompatibility," says Bordenstein. "We know very little about the virus, but understanding and using it may pave the way for future strategies to control insect-borne diseases."

Andrea Early | EurekAlert!
Further information:
http://www.mbl.edu

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>