According to the said researcher, this project “is part of the attempt that many laboratories are currently making worldwide to get to know better the biology of stem cells and the conditions in which some of their varieties could be used to treat some diseases”. In this case, scientists are going to study neural stem cells of adult mouse brains which, after being differentiated from neurons in a lab, will be implanted into the damaged cerebral cortex of genetically identical mice.
As Carmen Estrada explained, there is a specific area in the adult rodents’ brain, the subventricular area, where new neurons are massively generated from neural stem cells during the animals’ life. Although this phenomenon does not exist in humans in normal conditions, stem cells have been also detected in that area, with the possibility of generating new neurons under certain circumstances.
With this project, researchers will obtain information about neural stem cells that remain in the brain after birth, and will analyse their properties while they are in lab cultures, as well as after being implanted into the host brain.
Scientists hope to determine the conditions that allow neuron differentiation and to identify potentially useful genes as regulators or markers of such process. Thus, they will determine to what extent the neurons obtained in culture have the typical molecular structure of cells of its phenotype in adult brains.
In short, these trials will allow to establish “whether or not suitable neurons from neural stem cells can be transplanted into the brain of another animal”. The results will allow scientists to get to know the evolution of transplants and provide useful data in order to develop a cellular therapy as part of the treatment of some diseases linked to neuronal death.
Ismael Gaona | alfa
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy