Although these results are of greatest interest to the relatively small group interested in erythrovirus (parvovirus) research, the ideas discussed are of wider interest because they explore in an imaginative way some fundamental biological events occurring during and after infection.
The research group lead by professor Klaus Hedman at the University of Helsinki have investigated by qualitative and quantitative molecular assays a large number of human tissue samples (birth-year range 1913-2000) and patient sera from the past two decades, for genomic DNA of new and previously known human erythrovirus types. They disclosed in human tissues erythrovirus genome persistence, which is ubiquitous and life-long, and represents a new source of information of our past – which they termed the Bioportfolio.
In the Bioportfolio the researchers observed that in Central and Northern Europe the newly found erythrovirus type 2 in occurrence was actually older than the virus prototype; and that the other recently found type 3 never attained wide circulation in the area during the 70-year observation period from the thirties to the present day. Thereby, the Bioportfolio constitutes at the individual level a new form of "medical record" for one’s infectious encounters. At the global and epidemiological level, it provides a novel database for analysis of the occurrence and circulation of microbial species and their variants.
Furthermore, in light of the previously shown integrity and full-length coding potential of the persistent macromolecular viral DNA genomes, the Bioportfolio might provide the desired long-term permanence for gene therapy vectors, which in the future could be designed in accordance with this innate characteristic of the human body.
Paivi Lehtinen | alfa
When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short
23.03.2017 | Institut für Pflanzenbiochemie
WPI team grows heart tissue on spinach leaves
23.03.2017 | Worcester Polytechnic Institute
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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