The research group has previously shown that the QKI gene is a possible contributing cause of the disease schizophrenia. Now the scientists have found that QKI normally regulates the myelin genes, that is, the genes that govern the production of myelin, the insulation material for nerve fibers.
Moreover, the research team can show that the genetic expression of QKI is altered in schizophrenic patients and that the change correlates directly with the change in the myelin gene expression.
“In schizophrenics, fewer myelin proteins and less myelin are produced, we believe. Since myelin functions as an insulating substance around nerve fibers, impulse transmission is hampered in schizophrenics,” explains Elena Jazin.
The team of scientists has also seen that a variant of QKI called 7kb is the variant that changes most in schizophrenic patients. This 7kb also has a major effect on the expression of myelin genes in these patients.
“Just how the reduction of myelin affects the symptoms in schizophrenic patients is something we must investigate further,” says Elena Jazin.
It is hoped that the new findings will lead to improved treatment of schizophrenia in the future.
“We hope that existing drugs can be altered so that more patients will be helped and the side effects reduced. Perhaps the findings will also lead to new medicines. But this will require research and will take a long time,” says Elena Jazin.
Schizophrenia is one of the most common psychiatric public health disorders, affecting an average of one percent of the population of the world. Today’s methods of treatment can partially alleviate the symptoms, but many patients are not helped at all by them. Normally patients become ill between the ages of 15 and 30 and remain so for the rest of their lives.
The Uppsala University scientists in the research group are, besides Elena Jazin, Karolina Åberg and Peter Saetre. Niclas Jareborg has participated from AstraZeneca.
Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie
Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
21.04.2017 | Physics and Astronomy
21.04.2017 | Health and Medicine
21.04.2017 | Physics and Astronomy