Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Altering genetic blueprint of receptors in brain could help stroke victims avoid brain damage

12.04.2006
A University of Central Florida researcher has demonstrated that altering AMPA receptors in animals improved their chances of surviving strokes and remaining healthier afterwards.

A University of Central Florida researcher has discovered that altering a receptor that mediates communication between nerve cells in the brain significantly improves animals’ chances of surviving strokes and allows them to remain healthier afterwards.

YouMing Lu, a professor at the UCF Burnett College of Biomedical Sciences, is hopeful that changing the genetic blueprint of AMPA receptors can help to block lethal flows of calcium into neurons of human stroke victims.

If administered within a few hours of cardiac arrest, such therapies could prevent brain damage. Given later, the therapies could speed up the regeneration of neurons to replace ones killed by the stroke. In both cases, the primary goal is to help patients avoid brain injuries after strokes.

AMPA receptors that are located at the surface of nerve cells are normally responsible for learning and memory formation. During strokes, however, the receptors become toxic to nerve cells.

"We’re trying to find out what the major toxic aspects of these receptors are so we can rescue neurons without damaging learning and memory formation," Lu said.

Lu’s research was published in the March 2 issue of Neuron, a prestigious biomedical research journal. Lu and his research team at UCF and the University of Calgary are trying to determine the molecular functions that lead to receptors opening up and enabling large, lethal flows of calcium to reach neurons after strokes.

The calcium flows occur in the hippocampus of the brain, an area that is critical for learning and memory processes. The dilemma for researchers is to figure out how to protect neurons from the lethal doses of calcium without causing more damage to learning and memory.

Lu’s approach of modifying one part of the genetic blueprint of the AMPA receptor protected the brain in tests with mice and rats, which experience the same pattern of brain damage after cardiac arrest as humans do, Lu said. More tests in animals would be done before clinical trials are conducted.

Lu conducted his research with funds from the American Heart Association, plus other grants from the UCF presidential equipment fund, the Heart and Stroke Foundation of Canada and the Canadian Institute for Health Research. Lu’s research has potential future applications for Alzheimer’s disease and other neurological illnesses. Drug therapies for those diseases also could improve learning and memory by inducing the regeneration of neurons.

Lu began his research about six years ago at the University of Calgary. He moved to the University of Central Florida 1 1/2 years ago, when the university began hiring more faculty members in the Burnett College of Biomedical Sciences to develop a foundation for a new medical college at UCF.

Chad Binette | EurekAlert!
Further information:
http://www.ucf.edu

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>