Stem cell factor (SCF) is an important growth factor for multiple cell types. Research has shown that SCF is expressed in glioma cells and as a result of various types of brain injury, but its significance is not fully understood. Dr. Howard A. Fine from the National Cancer Institute/National Institute of Neurological Disorders and Stroke at the National Institutes of Health and colleagues designed a study to investigate whether, as a result of tumor-induced brain injury, brain cell-mediated SCF expression contributes to tumor growth by setting up an environment that supports angiogenesis and tumor progression.
The researchers demonstrate that decreased SCF expression in vivo results in decreased angiogenesis and improved survival in mouse glioma models, whereas overexpression of SCF is associated with a worse prognosis and shorter survival in patients with glioblastomas. SCF expression is not directly linked to tumor cell proliferation but instead encourages the growth of blood vessels needed to support the expanding tumor. Importantly, these findings provide definitive evidence that factors promoting tumor progression extend beyond the tumor itself and involve a complex interaction between the cancer cells and the normal cells that are perturbed by expanding tumor.
These results suggest that SCF is a potent glioma-associated angiogenic factor that plays a prominent role in pathological angiogenesis both through direct tumor cell expression of SCF and by normal neurons that are damaged by the growing tumor. The researchers point out that the clinical significance of these findings extends beyond identification of SCF as a rational target for gliomas. "Normal neuronal expression of SCF in response to traumatic brain injury also raises the disturbing possibility that standard invasive procedures such as surgical biopsies or partial tumor resections may be inducing a proangiogenic response, or trigger, within the brain," cautions Dr. Fine.
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22.03.2017 | Universität Augsburg
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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