Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Towards a unified model of transcription termination

10.04.2006
Dr. David Bentley (University of Colorado School of Medicine) and colleagues have developed a new, unified model for transcription termination by RNA Poymerase II. Over the years, research into the mechanism of poly(A) site-dependent transcription termination has generated two different models: the allosteric and the torpedo models.

The allosteric, or antiterminator, model proposes that transcription of the poly(A) site triggers conformational changes that destabilize the elongating RNA polymerase, resulting in termination. The torpedo model proposes that an exonuclease degrades the nascent RNA, and eventually catches up to the elongation complex, causing its termination.

Using a novel experimental system to study the function of the exonuclease Rat1 in yeast, Dr. Bentley’s team now shows that while the exonucleases Rat1 and Xrn1 do degrade the nascent RNA transcript, this degradation is not sufficient to cause polymerase termination. Rather, Rat1 helps recruit cleavage and polyadenylation factors that are necessary for termination. "As is often the case with competing hypotheses like the torpedo and allosteric models for transcription termination, neither one can explain the whole story, but aspects of both are correct, and these form the basis for a unified model," explains Dr. Bentley.

Heather Cosel | EurekAlert!
Further information:
http://www.cshl.edu

More articles from Life Sciences:

nachricht First line of defence against influenza further decoded
21.02.2018 | Helmholtz-Zentrum für Infektionsforschung

nachricht Helping in spite of risk: Ants perform risk-averse sanitary care of infectious nest mates
21.02.2018 | Institute of Science and Technology Austria

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

MEMS chips get metatlenses

21.02.2018 | Physics and Astronomy

International team publishes roadmap to enhance radioresistance for space colonization

21.02.2018 | Physics and Astronomy

World's first solar fuels reactor for night passes test

21.02.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>