Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Signaling proteins may represent biomarkers for melanoma

06.04.2006
For the first time, researchers studying patients with abnormal moles have identified proteins that could help predict whether such moles will progress into melanoma, the deadliest form of skin cancer. The study provides promising evidence that the proteins may represent potential biomarkers for prevention therapy. The results were announced today at the annual meeting of the American Association for Cancer Research (AACR), at the Washington Convention Center in Washington, D.C. The study, abstract number 5742, also looked at the effect of a common treatment for melanoma, interferon, on the levels of these biomarker proteins.

While investigating the mechanisms of action of interferon treatment on patients at high risk for melanoma recurrence who had multiple abnormal moles, investigators found that two intracellular signaling proteins called signal transducers and activators of transcription, STAT1 and STAT3, were correlated with the degree of mole abnormality when examined under a microscope. The researchers also found that interferon regulated the proteins in a manner that was dependent on its dose.

"While abnormal moles are a major risk factor for new primary melanoma development, it is difficult to know who among these patients will eventually develop the disease," said principal investigator John Kirkwood, M.D., professor of medicine at the University of Pittsburgh and director of the Melanoma Center at the University of Pittsburgh Cancer Institute (UPCI). "Rather than aggressively treating all of these patients, our hope with further study is to potentially test for these proteins and select those patients most likely to benefit from specific doses of interferon therapy."

In the study, researchers treated 40 patients at various levels of risk for recurrence of melanoma with interferon administered at either high or low doses. They then examined changes in the appearance of the patients’ moles under a microscope and used molecular markers to determine the expression levels of STAT1, a protein associated with anti-tumor effects, and STAT3, a protein linked to melanoma progression. They found that the more severe the pathologic abnormality of the mole, the greater the level of STAT3 expression. Results also indicated that after high-dose interferon the level of STAT 1 increased 7.8 times and after low-dose interferon it increased 1.4 times over pretreatment levels. In contrast, STAT3 was reduced by 55 percent with high doses of interferon and by 39 percent with low doses. The ratio of STAT1 to STAT3 best represented the impact of interferon, increasing 23 times with high dose interferon and 2.6 times with low doses.

"Our study found that interferon regulates expression of STAT1 and STAT3 in a dose-dependent manner and provides a useful biomarker of interferon impact on these well- established precursor lesions, which have the potential to become cancerous," said Dr. Kirkwood. "This suggests that these markers will be important to follow in our efforts to prevent the new development of melanoma in the skin of our patients, as well as melanoma recurrence."

According to American Cancer Society predictions, an estimated 62,190 new cases of melanoma are expected in 2006 and 7,910 deaths are expected to occur.

Clare Collins | EurekAlert!
Further information:
http://www.upmc.edu

More articles from Life Sciences:

nachricht For a chimpanzee, one good turn deserves another
27.06.2017 | Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPIMIS)

nachricht New method to rapidly map the 'social networks' of proteins
27.06.2017 | Salk Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Touch Displays WAY-AX and WAY-DX by WayCon

27.06.2017 | Power and Electrical Engineering

Drones that drive

27.06.2017 | Information Technology

Ultra-compact phase modulators based on graphene plasmons

27.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>