Carbon levels are sensed by a biological molecule, adenylyl cyclase (AC), that can then affect sperm motility or the virulence of a dangerous human pathogen. So far, AC is the only signalling molecule known to directly respond to inorganic carbon. Dr Martin Cann will present this work at the Society for Experimental Biology Annual Main meeting at the University of Kent, Canterbury on Monday 3rd April [session A1].
Dr Cann’s group have been studying the effects of increased levels of inorganic carbon (Ci) on Pseudomonas aeruginosa, a pathogen that causes an array of infections in weakened patients and is renowned for being difficult to treat with antibiotics. They have found that increased levels of Ci inhibit an AC required for host cell invasion. “This suggests that the bacterium’s sensitivity to Ci could potentially make this detection pathway an attractive target for the development of new anti-bacterial drugs”, says Cann. “In theory, if you could increase the amount of Ci available locally to P. aeruginosa then you could stop it infecting the host.”
The AC-enzyme is also known to send a cascade of signals that regulate mammalian sperm motility in response to Ci – a consequence that has implications for human reproduction, perhaps in the treatment of infertility.
Dr Cann is learning more about the role of AC in carbon-detection using cyanobacteria and will report that, in conditions of elevated environmental CO2, AC is essential for full cyanobacterial motility.
Lucy Moore | alfa
Unique genome architectures after fertilisation in single-cell embryos
30.03.2017 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
Transport of molecular motors into cilia
28.03.2017 | Aarhus University
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
30.03.2017 | Physics and Astronomy
30.03.2017 | Studies and Analyses
30.03.2017 | Life Sciences