Testosterone has been associated with a higher rate of certain cancers. Classically, testosterone passes through the cell membrane to act inside the cell. However recent work has indicated that testosterone may also act at the cell surface, through membrane androgen binding sites called Ambs.
Now a team lead by Professors Stournaras, Castanas and Gravanis at the Medical School of the University of Crete Heraklion, Greece, has discovered that activating these cell-surface testosterone binding sites can significantly reduce the size of prostate cancer tumours in animal models.
When testosterone is bound to another protein such as BSA, it does not enter the cell, and so can only be expressed at the cell membrane, activating newly identified specific signalling pathways. The University of Crete team treated mice, which had been given prostate cancer through inoculation with LNCaP cancer cells. They found that after one month of treatment with testosterone bound to the protein BSA (Bovine Serum Albumin) there was a 60% reduction in tumour size, with no apparent side-effects.
Professor Stournaras said:
This work strongly supports the concept that testosterone-protein conjugates, which activate membrane androgen receptors may represent a new class of experimental anti-tumour agents in prostate cancer. This is a new concept, and we need to make sure that these results can be transferred to humans in a satisfactory way. But if we can develop drugs that act safely on these Ambs (androgen membrane binding sites) then we may have a completely new therapeutic option for prostate cancer.
Jo Thurston | alfa
Making fuel out of thick air
08.12.2017 | DOE/Argonne National Laboratory
‘Spying’ on the hidden geometry of complex networks through machine intelligence
08.12.2017 | Technische Universität Dresden
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
08.12.2017 | Event News
07.12.2017 | Event News
05.12.2017 | Event News
08.12.2017 | Life Sciences
08.12.2017 | Information Technology
08.12.2017 | Information Technology