Testosterone has been associated with a higher rate of certain cancers. Classically, testosterone passes through the cell membrane to act inside the cell. However recent work has indicated that testosterone may also act at the cell surface, through membrane androgen binding sites called Ambs.
Now a team lead by Professors Stournaras, Castanas and Gravanis at the Medical School of the University of Crete Heraklion, Greece, has discovered that activating these cell-surface testosterone binding sites can significantly reduce the size of prostate cancer tumours in animal models.
When testosterone is bound to another protein such as BSA, it does not enter the cell, and so can only be expressed at the cell membrane, activating newly identified specific signalling pathways. The University of Crete team treated mice, which had been given prostate cancer through inoculation with LNCaP cancer cells. They found that after one month of treatment with testosterone bound to the protein BSA (Bovine Serum Albumin) there was a 60% reduction in tumour size, with no apparent side-effects.
Professor Stournaras said:
This work strongly supports the concept that testosterone-protein conjugates, which activate membrane androgen receptors may represent a new class of experimental anti-tumour agents in prostate cancer. This is a new concept, and we need to make sure that these results can be transferred to humans in a satisfactory way. But if we can develop drugs that act safely on these Ambs (androgen membrane binding sites) then we may have a completely new therapeutic option for prostate cancer.
Jo Thurston | alfa
Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz
Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences