A team led by U-M chemical engineering professor Walter J. Weber Jr. tagged multi-walled carbon nanotubes—one of the most promising nanomaterials developed to date—with the carbon-14 radioactive isotope, which enabled the nanotubes to be tracked and quantified as they were absorbed into living cells. Researchers used cancer cells called HeLa cells, and also measured nanotube uptake in an earthworm and an aquatic type of worm.
The findings were presented Sunday at the 231st American Chemical Society National Meeting in Atlanta. Co-authors of the presentation are graduate student Elijah Petersen and postdoctoral research assistant Qingguo Huang.
Carbon nanotubes were discovered in 1991, and hold great promise in several areas, including pharmacology and for hydrogen storage in fuel cells, Weber said. But despite their promise, a big problem is that it’s not known how multi-walled carbon nanotubes will impact the living environment, Weber said.
"While everyone is concerned about this issue, there has been no really adequate way before this development to examine the extent to which they may get into human cells, and what will result if they do," Weber said. "Nobody has been able to do quantitative research on this because no method to measure them has existed until now. We were able to detect them, but had no way to determine how much was there."
In tagging the nanotubes with the isotope, researchers found that about 74 percent of the nanotubes added to a culture of cancer cells were assimilated by the cells after 15 minutes, and 89 percent of nanotubes assimilated after six hours, according to the paper. And the uptake was nearly irreversible, with only about 0.5 percent of the nanotubes releases from the cell after 12 hours.
It’s important to understand if and how the multi-walled carbon nanotubes accumulate in living cells, because before the materials can become widely used in society scientists must understand if they’ll pass through the food webs and possibly threaten the health of ecosystems and lead to uptake by humans, Petersen said.
"This approach has virtually limitless potential for facilitating important future investigations of the behaviors of carbon nanotubes in environmental and biomedical applications," Petersen said.
More information on Prof. Weber.
The University of Michigan College of Engineering is ranked among the top engineering schools in the country. Michigan Engineering boasts one of the largest engineering research budgets of any public university, at $135 million for 2004. Michigan Engineering has 11 departments and two NSF Engineering Research Centers. Within those departments and centers, there is a special emphasis on research in three emerging areas: nanotechnology and integrated microsystems; cellular and molecular biotechnology; and information technology. Michigan Engineering is seeking to raise $110 million for capital building projects and program support in these areas to further research discovery. Michigan Engineering’s goal is to advance academic scholarship and market cutting edge research to improve public health and well-being.
Scientists spin artificial silk from whey protein
24.01.2017 | Deutsches Elektronen-Synchrotron DESY
Choreographing the microRNA-target dance
24.01.2017 | UT Southwestern Medical Center
A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
24.01.2017 | Physics and Astronomy
24.01.2017 | Life Sciences
24.01.2017 | Health and Medicine