The glow emitted by a variety of sea coral helped Russian scientists harness the protein that generates the light to create a tiny fluorescent tag that responds to visible light. The two-color tag should help researchers follow individual proteins as they dart around inside living cells.
An image of a single mamalian cell with green-to-red fluorescent Dendra marking fibrillarin, a protein concentrated in nucleoli, which are small, round bodies in the cells nucleus, composed of protein and RNA. Image: Sergey Lukyanov
Under a microscope, the two-color tag—called Dendra because it is derived from the sea coral Dendronephthya—first shows up as a green glow, highlighting the otherwise invisible protein to which it is attached. The green turns to red when the tags are zapped with an intense pulse of visible blue light.
The dramatic color change "makes it possible to precisely label an object, such as a cell, organelle, or protein, with a flash of light and then to follow the objects movement over time," said Konstantin Lukyanov, whose group conducted the Dendra research in the lab of his brother, Sergey Lukyanov, a Howard Hughes Medical Institute (HHMI) international research scholar at the Institute of Bioorganic Chemistry of the Russian Academy of Sciences in Moscow. "This tool opens new possibilities for studying protein and organelle dynamics in living cells, cell migration during embryogenesis, inflammation, and other pathological and normal processes," he said.
Jennifer Donovan | EurekAlert!
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The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
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With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
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An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
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Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
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08.12.2017 | Information Technology