Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers link human papillomavirus (HPV) to common skin cancer

15.03.2006


Human papillomavirus (HPV) may be a risk factor in developing squamous cell carcinoma, a common form of skin cancer, according to research led by Dartmouth Medical School. The study, published in the March 15 issue of the Journal of the National Cancer Institute, used new technology to detect antibodies from a strain of HPV on skin cancer samples.



"We found a virus that may be a risk factor for skin cancer," said lead investigator Dr. Margaret Karagas, of Dartmouth Medical School’s Norris Cotton Cancer Center. "Although sun exposure and sensitivity to sun are still the main culprits in skin cancer, our findings suggest skin types of HPV also may play a role in the development of squamous cell carcinomas."

Previous research has found a relationship between cancer of the cervix and "alpha" or mucosal types of HPV. Karagas and her team focused their research on the skin types or "beta" HPVs. The research team searched for beta HPV antibodies in plasma samples from 252 patients with squamous cell carcinoma, 525 patients with basal cell carcinomas and 461 control subjects.


Using multiplex serology, a new method based on fluorescent bead technology that detects viral antibodies, the authors detected HPV antibodies in patients diagnosed with squamous cell carcinoma more frequently than in the control subjects. The researchers did not detect a presence of HPV in the patients with basal cell carcinomas more frequently than controls.

"This makes sense because we have known that patients who are taking immunosuppressive drugs, such as organ transplant recipients have a tendency to develop squamous cell skin cancers, and that their tumors frequently contain these beta type HPVs," said Karagas.

In addition to searching for HPV antibodies in the samples, the researchers conducted one-on-one interviews with the study participants to gage other skin cancer factors that could play a role in the study’s results. Participants were asked about lifestyle habits, including whether they smoked or drank, medical and family history, and their usual level of sun exposure and their skin’s sensitivity to sun. Taking all these other factors into account, the researchers still found an association between HPV and squamous skin cancer.

"While further study is needed, a potential role of viruses in skin cancer occurrence could represent a new line of investigation for the detection and treatment of squamous cell skin cancer," said Karagas. The authors note that although they identified an association between HPV antibodies and squamous cell carcinoma risk, more studies must be done to establish a direct causal link.

Andy Nordhoff | EurekAlert!
Further information:
http://www.dartmouth.edu

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>