Scientists have uncovered new information about what orchestrates the complex balance between blood stem cells and mature blood cells, a relationship that is often disrupted in leukemia. The results, published in the March issue of Cancer Cell, will lead to a better understanding of the behavior of leukemic cells and may have vital clinical applications for patients recovering from chemotherapy, radiation therapy, or bone marrow transplantation.
Recent studies have implicated reduced levels of a transcription factor called MEF with subtypes of leukemia. Drs. Stephen D. Nimer and Daniel Lacorazza from Memorial Sloan-Kettering Cancer Center and colleagues examined the blood cells of mice that do not express MEF in their bone marrow and found an increased population of hematopoietic (blood-forming) stem cells (HSCs). HSCs are immature cells in the bone marrow that have the capacity to differentiate into all types of mature blood cells. A delicate balance exists between self-renewal and differentiation of HSCs because the body must retain a sufficient population of HSCs while continually producing the multitude of new blood cells that are needed each day.
The researchers demonstrated that MEF regulates a little-understood state of quiescence that enables HSCs to exist in a kind of suspended animation until they are recruited to promote rapid repopulation of depleted blood cells, as would be needed following treatment with chemotherapy or radiation therapy. MEF-deficient mice accumulated quiescent HSCs with the capacity for repopulation and demonstrated enhanced resistance to the effects of chemotherapeutic drugs and radiation, which is also seen in wild-type mice transplanted with MEF-deficient HSCs. "This feature can also be helpful to maintain HSCs in an undifferentiated state during gene therapy protocols," explains Dr. Lacorazza, now a faculty member at Baylor College of Medicine.
Joanne Nicholas | EurekAlert!
Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg
Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Trade Fair News
23.02.2018 | Life Sciences