Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Do plants have the potential to vaccinate against HIV?

14.03.2006


Fusion molecules could be the key to producing vaccines from plants



Scientists have developed a new kind of molecule which they believe could ultimately lead to the development of a vaccine against HIV using genetically modified tobacco. Writing in Plant Biotechnology Journal, Dr Patricia Obregon and colleagues from St George’s, University of London along with researchers at the University of Warwick say they have overcome a major barrier that has so far frustrated attempts to turn plants into economically viable “bioreactors” for vaccines.

By creating fusion molecules, the researchers have found a way to make plants produce more of the molecules (antigens) needed for vaccines. At the same time, they may also have discovered a way of producing better targeted vaccines.


Obregon and her colleagues in Dr Julian Ma’s laboratory are working with the p24 core protein of the Human Immunodeficiency Virus (HIV). This protein plays a central role in eliciting the immune response to HIV infection, and is therefore likely to be an integral part of any multicomponent vaccine for HIV.

Plants have already been used to produce many types of vaccine molecules, but a consistent problem has been achieving adequate levels of protein expression in order to make them viable as bioreactors for vaccines.

Obregon and her colleagues have found a way to significantly boost HIV-1 p24 protein production in plants by producing an entirely new molecule – a fusion of the HIV-1 p24 protein and part of another protein, human immunoglobulin A (IgA) - a major component of the immune system. The team found that the HIV-1p24 antigen produced in this way elicited appropriate immune response in mice.

The results have important implications for the economic viability of using plants as bioreactors to produce vaccines against HIV and other diseases. According to Obregon: “Using antibody-antigen fusion molecules may represent a generic strategy to increase the expression of recombinant proteins in plants. It could open the door to cheaper biopharmaceuticals. Plant-derived pharmaceuticals are of great interest because of their enormous potential for economy and scale of production. This technology could lead to production of modern medicines that will also be accessible to poor populations in developing countries – which is where these medicines are needed the most.”

The results could also lead to the development of more effective vaccines. By using specific immunoglobulin sequences in the fusion molecule, antigens could be targeted to specific cells in the immune system, the authors say.

Davina Quarterman | alfa
Further information:
http://www.blackwell-synergy.com/doi/full/10.1111/j.1467-7652.2005.00171.x

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>