Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Simple test could predict major complications in sickle cell patients

08.03.2006


Researchers have found that a simple test for an enzyme called LDH may have significant importance for determining major risk factors in adults with sickle cell disease. The study results will be published in the March 15, 2006, issue of Blood, the official journal of the American Society of Hematology.



"This study suggests that LDH testing may be a worthwhile addition to ’well adult’ visits for individuals with sickle cell anemia, though the significance in children and adolescents, remains unclear," said Zora Rogers, MD, Associate Professor of Pediatrics at The University of Texas Southwestern Medical Center in Dallas, who is not affiliated with the study.

LDH, or lactate dehydrogenase, is found in many different types of cells in the body, but is particularly rich in the red blood cells, heart, kidney, liver, and muscles. When these organs become diseased, the cells containing LDH release the enzyme, resulting in elevated LDH levels in the bloodstream.


In this study, patients with all forms of sickle cell disease – 213 adults in all – had their LDH levels measured with a blood test. Based on these values, the patients were categorized into three groups – low, medium, and high LDH. The LDH values were then reviewed in light of each patient’s medical history.

Typically, the upper limit of LDH in healthy adults is 200 IU/L (international units per liter). The 31 patients in the high group had LDH values of 512-1171 IU/L, correlating to a history of medical complications, in particular, leg ulcerations and priapism. The patients’ LDH values were also compared to their rates and severity of pulmonary hypertension, a build-up of pressure in the arteries that supply the lungs and a common complication of sickle cell disease. The researchers found that LDH values rise with severity of pulmonary hypertension.

In addition, mortality rates for the study participants were examined over a follow-up period of 49 months. Researchers found that patients with LDH values higher than the median had reduced survival compared to those with LDH values lower than the median. These data suggest that high LDH values may predict early mortality in patients with sickle cell disease.

The results of the study indicate that high LDH levels can define a subgroup of sickle cell patients who are significantly more likely to have serious complications such as pulmonary hypertension, leg ulcerations, and priapism, and are at increased risk of early mortality. Interestingly, these correlations held whether or not patients were taking hydroxyurea, the standard treatment for the disease, and LDH values were not associated with episodes of pain crisis, the hallmark of sickle cell anemia.

The source of LDH in these patients appears to be primarily from the breakdown of fragile red blood cells, consistent with recent published findings suggesting that red blood cell contents released into the bloodstream over a period of years may cause diseased blood vessel walls.

"LDH levels illuminate a pattern of pathology in sickle cell disease patients," said Gregory Kato, MD, of the National Institutes of Health and lead study author. "As a result, LDH appears to hold great promise as an effective indicator for identifying patients most at risk and in need of possible preventive care and careful monitoring."

Laura Stark | EurekAlert!
Further information:
http://www.hematology.org
http://www.bloodjournal.org

More articles from Life Sciences:

nachricht New catalyst controls activation of a carbon-hydrogen bond
21.11.2017 | Emory Health Sciences

nachricht The main switch
21.11.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Previous evidence of water on mars now identified as grainflows

21.11.2017 | Physics and Astronomy

NASA's James Webb Space Telescope completes final cryogenic testing

21.11.2017 | Physics and Astronomy

New catalyst controls activation of a carbon-hydrogen bond

21.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>