Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Major biomarker candidates for Alzheimer’s disease explored: holds promise for improving the diagnosis and ...

08.03.2006


... Management of Dementia



Alzheimer’s disease--specific biomarkers clearly are needed for the differential diagnosis of cognitive impairment in the elderly. What sets age-related disorders like hypertension, hypercholesterolemia and diabetes mellitus apart from Alzheimer’s disease is that each has biomarkers that can be followed easily and repeatedly, not simply to diagnose, but also to monitor response and optimize treatment. In contrast, the current role of clinical laboratory evaluation for dementia is exclusionary. The development of such biomarkers is critical to translating efficiently the new therapeutic approaches for AD under development by many research groups into treatments for the millions who suffer from AD.

The March issue of the Journal of Alzheimer’s Disease (www.j-alz.com) published by IOS Press is devoted to the current research into "Biomarkers for Alzheimer’s Disease.” In the foreword by Elaine R. Peskind and guest editor Thomas J. Montine (University of Washington), the challenges and limitations of our current knowledge of AD biomarkers are outlined. These investigators emphasize that "Progress toward controlling if not eradicating AD is at a crossroads where clinical, pathological and basic science studies have identified therapeutic targets that are now being tested. Critical to translating this knowledge to improved patient care will be developing panels of biomarkers that complement the clinical exam, cognitive testing, and neuroimaging." In six articles, prominent researchers and clinicians involved in AD studies review the search for potential biomarkers for this debilitating disease.


Jeffrey L. Cummings (University of California at Los Angeles) discusses the use of clinical evaluation as a biomarker for AD, pointing out the need for biomarkers that accurately reflect clinical outcomes.

Following this theme, Douglas Galasko (University of California at San Diego) reviews some of the current candidates for AD biomarkers, such as amyloid-beta, tau, and phospho-tau. Other biomarkers that target inflammatory and oxidative damage processes may have future potential.

In a disease with no known cure and no treatments that can delay onset or prevent progression, prediction of future pathology is particularly important. In “The search for antecedent biomarkers of Alzheimer’s disease,” Anne M. Fagan, Cynthia A. Csernansky, John C. Morris, and David M. Holtzman (Washington University in St. Louis), discuss some of the challenges surrounding the development of biomarkers for “preclinical AD.”

Thomas J. Montine, Joseph F. Quinn, Kathleen S. Montine, Jeffrey A. Kaye, and John C.S. Breitner (University of Washington and Oregon Health & Science University), in “Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer’s disease,” discuss how the monitoring of F2-isoprostanes in cerebro-spinal fluid (CSF) is showing promise as a diagnostic tool for monitoring potential anti-oxidant therapies for AD.

Inflammatory processes have also been implicated in AD. Robert E. Mrak and W. Sue T. Griffin (University of Arkansas) review proinflammatory cytokines as potential markers for AD, pointing out in “Inflammatory biomarkers in Alzheimer’s disease” the difficulties in the use of such markers due to complicating genetic factors.

Finally, Jing Zhang, David R. Goodlett, and Thomas J. Montine (University of Washington) discuss recent advances in genomics, proteomics, and metabolomics. In “Proteomic Biomarker Discovery in Cerebrospinal Fluid for Neurodegenerative Diseases,” the prospect for clinical diagnosis via unique protein markers is reviewed, as well as the practical limitations of proteomic analysis of human CSF.

In addition to the articles, the issue features transcripts of two live panel discussions of the Alzheimer Research Forum, “Imaging in Alzheimer’s Disease: The Current State of Affairs” and “Making a BioMark on Alzheimer Disease.” (The Alzheimer Research Forum, founded in 1996, is the web’s most dynamic scientific community dedicated to understanding Alzheimer’s disease and related disorders.)

Astrid Engelen | alfa
Further information:
http://www.j-alz.com

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>