Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Against pulmonary fibrosis

07.03.2006


The biotech companies Digna Biotech and Biotherapix have signed an agreement to jointly apply their patented products towards the development of a treatment for pulmonary fibrosis. Digna Biotech is the commercial entity responsible for developing the intellectual property (patents) generated by the CIMA of the University of Navarra in its preclinical, clinical and commercial research.

The focal points of this agreement are the M3 protein owned by Biotherapix and the p17 peptide from Digna Biotech. It is hoped that these two compounds can work in common, taking advantage of the chemokyne inhibiting activity of M3 and the specific TGF-beta1 inhibiting activity of p17. Both TGF-beta1 as well as the chemokynes are key molecules in various inflammatory and degenerative processes. The researchers believe that the combined action of M3 and p17 will allow the development of a viable therapeutic alternative for treating pulmonary fibrosis.

The necessary studies for the development of the treatment us the p17 peptide and the M3 protein will be preferentially performed in centers of the University of Navarra: the CIMA, the University Hospital and the CIFA (Center for Research in Applied Pharmacobiology).



Combination of the p17 peptide and the M3 protein

The causes of pulmonary fibrosis are poorly known; this disease is characterized by an abnormal accumulation of collagen fibers in the lung, which causes structural deterioration. This deterioration causes progressive scarring in the lungs, which impedes the uptake of oxygen into the bloodstream, and thus impedes respiration. The European health authorities currently consider that pulmonary fibrosis is a rare or uncommon disease, with a prevalence of from 13 cases (in men) to 20 cases (in women) per 100,000 persons.

There do not currently exist effective treatments for this disease. The current treatments are based on the administration of oxygen and anti-inflammatories (glucocorticoids), some associated with immunosuppression and others not. These therapies have had limited success in reduction the progress of the fibrosis, and a contribute little to improving the quality of life of those affected.

The p17 peptide has demonstrated its effectiveness in the animal model which best reproduces pulmonary fibrosis. Currently, research is underway to confirm these findings with other models, and to begin toxicological studies. M3, on the other hand, is a protein of viral origin which has demonstrated its neutralizing effect against a wide set of molecules from the chemokyne family. Biotherapix is researching the use of derivatives of this molecule in order to slow certain inflammatory processes in which chemokynes play a key role. The M3 protein has shown advantages over other biological therapeutic molecules, such as its inhibiting activity against multiple chemokynes, as well as its low toxicity.

Irati Kortabitarte | alfa
Further information:
http://www.basqueresearch.com/berria_irakurri.asp?Gelaxka=1_1&hizk=I&Berri_Kod=911

More articles from Life Sciences:

nachricht Nesting aids make agricultural fields attractive for bees
20.07.2017 | Julius-Maximilians-Universität Würzburg

nachricht The Kitchen Sponge – Breeding Ground for Germs
20.07.2017 | Hochschule Furtwangen

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

Leipzig HTP-Forum discusses "hydrothermal processes" as a key technology for a biobased economy

12.07.2017 | Event News

 
Latest News

Researchers create new technique for manipulating polarization of terahertz radiation

20.07.2017 | Information Technology

High-tech sensing illuminates concrete stress testing

20.07.2017 | Materials Sciences

First direct observation and measurement of ultra-fast moving vortices in superconductors

20.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>