The thyroid gland is very sensitive to ionizing radiation. The number of patients with thyroid gland cancer is particularly high among those who endured the Chernobyl catastrophe in childhood. Ultrasonic scanning and bioptic tests investigations are usually used for early detection of thyroid gland cancer but researchers do not stop the search of more efficient methods.
They deal with molecular markers of cancer in order to discover mutation of the genes participating in carcinogenesis. Unfortunately, the existing methods for search of mutant genes are labour-intensive and expensive, therefore they do not fit for mass use. However, there is no need to seek changes particularly in oncogenes. In case of malignant transformation, mutation frequency increases in all cells of the organism.
Thus, European researchers have discovered that people with increased frequency of chromosomal abnormalities in lymphocytes of blood more often fall ill with cancer. According to Japanese and Russian researchers’ data, the patients suffering from larynx cancer and some other malignant growths, even before treatment starts experience increase of quantity of lymphocytes with T-cell receptor (TCR) genes mutations. These mutations are easy to discover via a special immunological test, which was used by the Obninsk physicians for search of mutant lymphocytes in blood of patients with thyroid gland cancer.
Sergey Komarov | alfa
BigH1 -- The key histone for male fertility
14.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)
Guardians of the Gate
14.12.2017 | Max-Planck-Institut für Biochemie
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