Researchers report the discovery that cells used in bone marrow transplantation can develop into new cells lining the gut, according to a study by Yale School of Medicine in the Proceedings of the National Academy of Sciences.
The study showed that bone marrow derived cells can differentiate into functional gastrointestinal epithelial cells after bone marrow transplantation. Research was from the laboratory of Diane Krause, M.D., professor of Laboratory Medicine and senior author of the study, in collaboration with Marie Egan, M.D., associate professor of pediatrics, respiratory medicine, and cellular and molecular physiology.
"We demonstrated that the cells were functional by showing that they express functional chloride channels (known as CFTR, or cystic fibrosis transmembrane conductance regulator) which are necessary for fluid balance in the gut," Krause said.
Jacqueline Weaver | EurekAlert!
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