Why do some overweight people stay healthy (apart from possible musculo-skeletal disorders) while obesity in other individuals leads to complications like diabetes and cardiovascular disease? The explanation lies in the genes. Scientists at the Department of Clinical Sciences at Lund University in Malmö, Sweden , have identified a gene that exists in a special variant in most overweight people, a variant that makes fatty acids “leak” into the blood stream, where they don’t belong.
Fat is constantly being metabolized by the body-being produced, broken down, and rebuilt. Adiponutrin is a protein that takes part in this process. But overweight people often have a variant of the adiponutrin gene that causes the amounts of this protein to be lower than normal.
“Adiponutrin is supposed to constitute a kind of ‘corset’ that keeps fat in its place in fatty tissue. If the protein doesn’t do its job after a sugar-rich meal, fatty acids leak into the blood instead. The high content of fat in the blood then affects the cardiovascular system, the liver, muscles, and pancreas,” explains Associate Professor Martin Ridderstråle.
Göran Frankel | alfa
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