Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Genetic background to ravages of obesity


Why do some overweight people stay healthy (apart from possible musculo-skeletal disorders) while obesity in other individuals leads to complications like diabetes and cardiovascular disease? The explanation lies in the genes. Scientists at the Department of Clinical Sciences at Lund University in Malmö, Sweden , have identified a gene that exists in a special variant in most overweight people, a variant that makes fatty acids “leak” into the blood stream, where they don’t belong.

Fat is constantly being metabolized by the body­-being produced, broken down, and rebuilt. Adiponutrin is a protein that takes part in this process. But overweight people often have a variant of the adiponutrin gene that causes the amounts of this protein to be lower than normal.

“Adiponutrin is supposed to constitute a kind of ‘corset’ that keeps fat in its place in fatty tissue. If the protein doesn’t do its job after a sugar-rich meal, fatty acids leak into the blood instead. The high content of fat in the blood then affects the cardiovascular system, the liver, muscles, and pancreas,” explains Associate Professor Martin Ridderstråle.

The difference between obese people who are healthy and those who develop diabetes and cardiovascular disorders may be the result of their having different variants of the adiponutrin gene and some other genes, he believes. The research team in Malmö is therefore busy developing a map of genes that can show what variants of key genes function as protection and as risk factors, respectively, in connection with these diseases.

“In the future this kind of mapping of an obese patient may be of significance in treatment. Certain medications, for example, might be more appropriate for people with certain gene variants. This opens the possibility of tailoring treatment to each individual,” says Martin Ridderstråle.

The research team’s findings on the adiponutrin gene are described in an article in the latest issue of the internationally recognized journal Diabetes.

Göran Frankel | alfa
Further information:

More articles from Life Sciences:

nachricht ‘Farming’ bacteria to boost growth in the oceans
24.10.2016 | Max-Planck-Institut für marine Mikrobiologie

nachricht Calcium Induces Chronic Lung Infections
24.10.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

Light-driven atomic rotations excite magnetic waves

24.10.2016 | Physics and Astronomy

More VideoLinks >>>