Biochemistry Professor Frank Sauer and colleagues uncover new information about how embryonic fruit fly cells differentiate, a process that may advance cancer and stem-cell research.
At left is a schematic showing how the Ash1 epigenetic activator interacts with the DNA of the fruit fly drosophila. At right is Ultrabithorax expression in the fruit fly wing.
Researchers at the University of California, Riverside have discovered a molecular mechanism that directs the fate and function of cells during animal development. The findings could hold promise for the advancement of cancer and stem-cell research.
The research is published in the Feb. 24 edition of the journal Science. UCR Biochemistry Professor Frank Sauer, with German colleague Elisabeth Kremmer of the Institut für Molekulare Immunologie in Munich, and fellow UCR researchers Tilman Sanchez-Elsner and Dawei Gou authored the paper titled, Noncoding RNAs of Trithorax Response Elements Recruit Dosphila Ash1 to Ultrabithorax.
Ricardo Duran | EurekAlert!
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