Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Masterminding muscle development

28.02.2006


Dr. Lizi Wu (Dana Farber Cancer Institute) and colleagues report on a critical role for one of the three mammalian mastermind genes (Maml1) in myogenesis – assigning that first biological function to the mammalian MAML Notch co-activators.



"Our study uncovered an exciting and essential regulatory role for Maml1 in muscle development," says Wu.

Dr. Wu and colleagues generated MAML1-deficient mice, which displayed severe muscular dystrophy. The researchers showed that the modulation of MAML1 expression levels in cell culture experiments directly impacts the ability of the muscle gene transcription factor, MEF2C, to induce myogenesis: Increased MAML1 expression leads to enhanced myotube formation and increased expression of muscle-specific target genes, while reduced MAML1 expression impairs muscle cell differentiation. It appears that MEF2C and MAML1 work together in a complex to "turn on" several other genes that are required for muscle development and function.


However, MAML1’s pro-myogenic effects are only observed when Notch receptors are inactive. The authors believe that MAML1 serves as a co-activator for MEF2C, but upon Notch activation, MAML1 is recruited away from MEF2C by Notch, thereby down-regulating muscle-specific target genes and up-regulating Notch target genes. "Our study uncovered an exciting and essential regulatory role for the Maml1gene in myogenesis and suggested that a mis-regulation of Maml1 gene function might contribute to the pathology of muscle myopathies," explains Dr. Wu.

There are two other genes that are similar to MAML1 in humans: MAML2 and MAML3, and Wu and colleagues are working to determine their functions as well.

Heather Cosel | EurekAlert!
Further information:
http://www.cshl.edu

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>