Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UVa Scientists Hot on Trail of Therapies for Deadly Lung Failure

23.02.2006


Researchers at the University of Virginia Health System have identified a molecular target, or receptor, for potential drugs to treat acute respiratory distress syndrome (ARDS), a sudden and life-threatening failure of the lung. Interestingly, the receptor is in the same class that gives people their sense of sight, smell and taste (G-protein coupled receptors.)



In ARDS, patients cannot breathe on their own because fluid gets into the lungs. Essentially, the body’s immune system causes lung inflammation and accumulation of fluid in the air sacs, or alveoli, leading to low blood-oxygen levels. Up to 30 percent of patients in intensive care units can die from ARDS. There is no current therapy other than general life support and putting patients on a breathing machine. If they survive, many people face long-term lung problems. Common causes of ARDS are pneumonia, septic shock, trauma, or inhaling chemicals.

The receptor identified by UVa doctors is called CXCR2. It’s expressed on the endothelial cells that line the blood vessels of the lung and on inflammatory leukocytes. Using animal models, UVa doctors have found that CXCR2 attracts white blood cells called neutrophils into the lung, a key event in the early development of ARDS. CXCR2 has been characterized in the past, but the endothelial cell effects define a new role for this receptor in the body’s physiology.


“We can’t say yet that if you target this receptor you will stop ARDS,” said Klaus Ley, M.D., Ph.D., director of the cardiovascular research center at UVa. “But it is reasonable to be hopeful and to pursue this type of research that might one day translate into clinical application.” Ley is senior author on a paper describing the receptor CXCR2 in the Feb. 16, 2006 “Online First Articles” of The Journal of Clinical Investigation found on the web at www.jci.org.

Dr. Jörg Reutershan, M.D., an anesthesiologist from Germany doing research in Ley’s lab, discovered that CXCR2 expressed on endothelial cells is involved in acute respiratory syndrome. “Our finding is that expression of this receptor is in the lung itself,” Reutershan said. “Our hope is that drug companies might be able to target the lung with an aerosol, which would have the advantage of hitting receptor without compromising the entire immune system, which is always a problem. Aerosol treatment would be a great advantage.”

The paper is titled “Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung.” 10.1172/JCI27009

Bob Beard | EurekAlert!
Further information:
http://www.jci.org
http://www.virginia.edu

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>