Shaped by much previous research, the prevailing view regarding sex-specific differences in the brain is that they are caused by circulating sex hormones, which are generated outside the brain and influence certain aspects of brain development, as well as brain function in adults. But new findings, reported by a team including Dr. Eric Vilain of UCLA, now reveal a new dimension to the influence of sex determination on brain function. The research shows that a single sex-specific gene plays a direct role in the brain by acting in neurons themselves, in addition to exerting an influence on the brain from afar through the action of hormones.
The researchers show that the mammalian gene SRY, which is the key sex-determination gene that directs gonads to develop as testes rather than ovaries, is also required in males for the normal function of a particular set of neurons in the adult mouse brain. These neurons secrete the neurotransmitter dopamine in the substantia nigra, a brain region that degenerates in Parkinsons disease.
SRY is passed from father to son on the Y chromosome and is not present in females. It is particularly intriguing that a gene that acts specifically in one sex is essential for the proper function of a certain set of neurons in males.
Heidi Hardman | EurekAlert!
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