Resveratrol prolongs lifespan and delays the onset of aging-related traits in a short-lived vertebrate
A natural compound could become the starting molecule for the design of drugs for the prevention of human aging-related diseases
A new study provides evidence that resveratrol, previously shown to extend lifespan in non-vertebrate organisms, can also do so in at least one vertebrate species. The findings support the potential utility of the compound in human aging research.
The development of drugs able to retard the onset of aging-related diseases and improve quality of life in the elderly is a growing focus of aging research and public health in modern society, and a great challenge for biotech and pharmaceutical industry. But the successful development of drugs aimed at aging-related diseases needs to face the challenge posed by the lifespan of the available animal models—mammalian models for aging are relatively long-lived and aren’t as easily studied as shorter-lived species.
Resveratrol is an organic compound naturally present in grapes—and particularly enriched in red wine—and was previously shown to prolong lifespan in non-vertebrate model organisms such as yeast, the worm C. elegans, and the fruit fly Drosophila. However, until now, life-long pharmacological trials were performed in the worm or fly model organisms because of their very small size, very short natural lifespan, and affordable cultivation costs. Laboratory mice, on the other hand, live more than two years and are relatively expensive to maintain, making large-scale, life-long pharmacological trials in mice unaffordable.
Recently, the seasonal fish Nothobranchius furzeri, a small fish species with captive lifespan of only three months, was described by Cellerino and colleagues; Lay Line Genomics a company focused on neurodegenerative and ageing related diseases, has developed this organism into a unique animal model to isolate new molecular targets controlling aging in vertebrates and for screening anti-aging compounds (T.Genade, M.Benedetti, E.Terzibasi, P.Roncaglia, D.R.Valenzano, A.Cattaneo, A.Cellerino: Annual fishes of the genus Nothobranchius as a model system for ageing research, Aging Cells, 2005)
The researchers used this short-lived fish as an animal model to test the effects of resveratrol on aging-related physiological decay. They added resveratrol to daily fish food and found that this treatment increased longevity and also retarded the onset of aging-related decays in memory and muscular performance.
Resveratrol appears to be the first molecule to consistently cause life extension across very different animal groups such as worms, insects, and fish, and it could become the starting molecule for the design of drugs for the prevention of human aging-related diseases. The use of resveratrol for ageing-related diseases as well as the use of Nothobranchius furzeri as a model for the study of aging and age-relate diseases is covered by Lay Line Genomics patents.
Dr. Jonathan Dando | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
Larsen C Ice Shelf rift finally breaks through
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...